Clobetasol + Salicylic Acid: View Uses, Side Effects

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Medically Reviewed by Dr. Aman Priya Khanna
Written by Sangeeta Sharma, last updated on 15 December 2023
Clobetasol + Salicylic Acid: View Uses, Side Effects

Clobetasol Propionate and Salicylic Acid ointment helps treat various skin concerns. It merges the anti-inflammatory power of Clobetasol Propionate with Salicylic Acid’s gentle exfoliation. Experience relief from troubling skin issues as the ointment sweeps away dull skin.

Clobetasol Propionate and Salicylic Acid ointment uses a strategic combination to combat skin concerns like eczema to psoriasis. This ointment targets and alleviates discomfort while promoting skin cell turnover. Continue reading to know more about the uses, benefits, and side effects of Clobetasol Propionate and Salicylic Acid ointment. 

Class of Medicine

Corticosteroid

Conditions Treated

Eczema and Psoriasis

Dosage

A thin layer two to three times daily

Formulation

Clobetasol Propionate and Salicylic Acid

Over-the-Counter Medicine

No

Habit Forming

No

About Clobetasol Propionate and Salicylic Acid Ointment

Clobetasol Propionate and Salicylic Acid ointment is a dermatological medication. It combines the therapeutic properties of two powerful ingredients. The harmonious blend of these ingredients targets the root causes of skin issues, offering immediate relief and long-term rejuvenation. The ingredients are:

  1. Clobetasol Propionate: It is a corticosteroid that blocks the production of chemical messengers (prostaglandins). These messengers trigger the inflammatory response, causing blood vessel dilation. This leads to redness, swelling, and itching in the affected area. Clobetasol Propionate relieves inflammation, itching, and redness associated with various skin conditions.

  2. Salicylic Acid: It is a keratolytic (compound that promotes the shedding of outer layers of the skin) medicine. It helps remove dead skin cells and improve skin texture. It enhances skin moisture levels. This effectively breaks down the substance that binds skin cells together. Salicylic Acid also improves the absorption of Clobetasol Propionate in the skin.

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Need for Clobetasol Propionate and Salicylic Acid Ointment

The ointment aims to address skin issues, alleviate discomfort and enhance the skin’s overall appearance. The uses ofClobetasol Propionate and Salicylic Acid ointment include treating the following conditions:

  1. Eczema: A condition characterised by dry, itchy, and bumpy skin. Symptoms may include a rash on the arms and behind the knees. 

  2. Psoriasis: A condition in which skin cells multiply to cause bumpy, scaly patches on the skin. Symptoms may include:

    1. Cracked, dry skin

    2. Itchiness

    3. Red patches

    4. Joint pain

    These symptoms most commonly occur on the scalp, knees, elbows, and lower back. 

Contraindications of Clobetasol Propionate Ointment

Clobetasol Propionate and Salicylic Acid ointment are contraindicated under certain circumstances due to potential risks and interactions. Contraindications include:

  1. Allergy to Clobetasol Propionate, Salicylic Acid, or similar medicines

  2. Acne or rosacea (redness and bumps on the face)

  3. Skin infection around the mouth

  4. Itchiness around private parts

  5. Itchy skin without any scaling

  6. Fungal, viral, or bacterial infection of the skin

  7. Chickenpox or herpes infection

Benefits of Clobetasol Propionate Ointment

Combining Clobetasol Propionate and Salicylic Acid offers several benefits for individuals dealing with specific skin conditions and concerns. However, the benefits of this ointment should be weighed against potential risks and contraindications before use. Some benefits of the ointment include:

  1. Anti-Inflammatory Action: Clobetasol propionate effectively reduces inflammation, itching, redness, and swelling resulting from skin conditions like eczema and psoriasis. It provides rapid relief and improved comfort.

  2. Skin Renewal: Salicylic Acid promotes gentle exfoliation by dissolving the bonds between dead skin cells. This reveals fresher, healthier skin underneath, aiding the treatment of certain skin conditions. 

  3. Improved Skin Texture: Regular ointment use can lead to smoother skin texture. It removes scaling and rough patches and reduces itchiness and redness caused by certain conditions.

Directions to Apply Clobetasol Propionate Ointment

Clobetasol Propionate and Salicylic Acid ointment is for external use only. The ointment should be applied two to three times daily or as prescribed by the healthcare professional. To ensure the safe and effective use of this ointment, individuals should follow these general directions:

  1. Clean and Dry: Start gently cleaning and patting the affected area dry. Do not apply the ointment on wet skin. 

  2. Apply Thin Layer: With clean hands, apply a thin layer of the Clobetasol Propionate and Salicylic Acidointment to the affected area. Individuals can also use a piece of clean cotton wool or a gauze swab to apply the cream. 

  3. Massage: Gently rub the ointment into the skin using circular motions. 

  4. Wash Hands: Patients should thoroughly wash their hands after applying the ointment unless the treatment is for their hands. 

Route of Administration

Clobetasol Propionate and Salicylic Acid ointment is applied through the cutaneous route. This means that the ointment is applied directly to the skin’s surface. The active ingredients get absorbed through the skin and exert their effects locally. 

Please note that the ointment is meant for external use only. It should not be consumed or applied to sensitive areas. 

Dosage Information

Clobetasol Propionate and Salicylic Acid ointment dosage is based on the area of skin being treated and the healthcare provider’s recommendations. 

Generally, the ointment is applied two to three times daily as a thin layer on the affected area. It should be applied as long as the doctor recommends, even if the symptoms improve. 

Missed Dose

If an individual misses a dose of Clobetasol Propionate and Salicylic Acid ointment, they should apply it as soon as they remember. However, if it is close to the time for the next dose, they should skip the missed dose. 

Instead, they should continue their regular dosing schedule. 

One should never apply a double dose to compensate for the missed one. Applying too much ointment can increase the risk of side effects.

Overdose

If someone suspects an overdose of the ointment, they should immediately remove any excess ointment from the skin. Individuals should seek medical attention if they experience any concerning symptoms or side effects.

Precautions While Using Clobetasol Propionate

When using the ointment, it is important to take certain precautions. These precautions can help ensure that the Clobetasol Propionate and Salicylic Acid ointment use is safe and effective. The following are some precautions to keep in mind:

  1. Follow Prescribed Duration: Always use the ointment exactly as the healthcare provider prescribes. Adhering to their instructions helps maximise benefits while minimising risks. 

  2. Avoid Prolonged Use: When applied for a prolonged duration, topical corticosteroids can lead to skin thinning and other adverse effects. 

  3. Avoid Tight Bandages: Unless directed by the healthcare provider, avoid covering the treated area with tight bandages or dressings. This can increase the risk of side effects.

  4. Do Not Apply on Open Wounds: Avoid applying the cream to open wounds, sunburns, lesions, and blisters. 

  5. Apply Moisturiser: Regularly use a mild moisturiser to prevent skin dryness during treatment. 

  6. Pregnancy and Breastfeeding: If a woman is pregnant, planning to become pregnant, or breastfeeding, they should consult their healthcare provider before using the ointment. This helps assess the potential risks and benefits of the ointment. 

  7. Avoid Naked Flames: Do not go near naked flames, as the fabric in contact with the ointment can easily catch fire. 

Side Effects of Clobetasol Propionate and Salicylic Acid

Clobetasol Propionate and Salicylic Acid ointment may have potential side effects like any medication. Not every individual will experience these side effects. 

Individuals with sensitive skin may have a higher risk than others. Common Clobetasol Propionate and Salicylic Acid side effects may include:

  1. Burning Sensation: Some people may feel a temporary burning or stinging sensation shortly after applying the ointment. This sensation is usually mild and short-lived.

  2. Itching: It can occur due to the ointment’s interaction with the skin. The itching may decrease with continued use.

  3. Redness: Some redness, particularly around the treated area, may occur as a response to the active ingredients in the ointment. It typically resolves on its own.

  4. Irritation: Skin irritation can manifest as redness, warmth, or a sensation of discomfort at the application site. This is a common side effect of many topical treatments.

Managing Side Effects

Experiencing side effects after using the Clobetasol Propionate and Salicylic Acid ointment is uncommon. Even when someone experiences these side effects, they are usually mild. Side effects can be managed with the following steps:

  1. Discontinue Use: Individuals should discontinue ointment use if they experience severe side effects like:

    1. Skin Irritation

    2. Burning

    3. Redness

    4. Itching

  2. Rinse With Water: If side effects are due to overuse of the medicine, individuals should remove the excess ointment and rinse the area thoroughly with water.

  3. Consult a Healthcare Professional: Seek medical attention if side effects persist or worsen. A healthcare professional can help manage side effects or recommend alternate treatments.

Drug-Drug Interaction

Clobetasol Propionate and Salicylic Acid ointment may potentially interact with other medications. It is important to inform the healthcare provider about all the medicines, supplements, and herbs a person takes. 

They should also inform about the topically applied cream, lotions and gel they use. Some medicines that should be used cautiously with ointment include:

  1. Ritonavir (used in treating HIV/AIDS)

  2. Itraconazole (treats fungal infections)

Drug-Food Interaction

Oral medications can be influenced by certain foods in the digestive system. However, Clobetasol Propionate and Salicylic Acid ointment is a topical medication with minimal systemic absorption. Therefore, it is not typically associated with significant drug-food interactions. 

Drug-Disease Interaction

Clobetasol Propionate and Salicylic Acid ointment may interact with certain medical conditions, affecting its safety or effectiveness. Before using this medication, individuals must discuss their medical history and health conditions with their healthcare provider. These conditions may include:

  1. History of allergic reactions to medicines

  2. Blood circulation issues

  3. Liver or kidney problems

  4. Chickenpox

  5. Cushing’s disease (excess level of the hormone cortisol)

Storage of Clobetasol Propionate and Salicylic Acid

Proper storage of Clobetasol Propionate and Salicylic Acid ointment is essential to maintain its effectiveness and safety. Following are the guidelines for storing the ointment:

  1. Cool and Dry Place: Store the ointment in a cool, dry place away from sunlight.

  2. Original Container: Keep the ointment in its original container to maintain its integrity and prevent cross-contamination.

  3. Close the Lid Tightly: Ensure that the cap or lid of the ointment container is tightly closed when not in use. This helps prevent the ointment from contamination or drying out.

  4. Keep Out of Reach of Children: The medicine should be kept away from children and pets to avoid misuse. 

  5. Check Expiry Date: Regularly check the expiry date of the ointment. Dispose of the ointment properly if it has expired.

Diet and Lifestyle Guidance

While using Clobetasol Propionate and Salicylic Acid ointment, maintaining a healthy diet and lifestyle can complement the treatment and promote overall skin health. The following are some general guidelines to consider:

  1. Balanced Diet: Eat a healthy diet rich in fruits, vegetables, whole grains, legumes, nuts, and fatty fish to support skin health.

  2. Hydration: Stay well-hydrated by drinking adequate water throughout the day. Hydrated skin reduces the risk of dryness and irritation.

  3. Limit Alcohol and Caffeine: Excessive alcohol and caffeine consumption can dehydrate the skin, potentially counteracting the positive effects of treatment.

  4. Manage Stress: Practice stress-reduction techniques like meditation, yoga, or deep breathing to manage stress.  

  5. Regular Exercise: Physical activity can improve blood circulation, promote skin health, and enhance overall well-being. 

  6. Adequate Sleep: Getting sufficient sleep supports skin regeneration, reduces inflammation, and aids in the body’s healing processes. 

  7. Mild Soap and Warm Baths: Using mild soap and warm baths can help gently cleanse the skin, maintain its natural moisture balance, and soothe irritation.

  8. Minimise Scratching: Do not scratch the affected skin. This prevents the spread of infection or inflammation to other body parts.

  9. Personal Items and Hygiene: Not sharing personal items like towels, combs, and bed sheets reduces the risk of cross-contamination and spreading infections. Regularly washing bed sheets and towels helps maintain a clean environment for healing.

  10. Loose-Fitting Clothes: Wearing loose-fitted clothes reduces sweat buildup, which can contribute to infection spread.

Price of Clobetasol Propionate and Salicylic Acid Ointment

Clobetasol Propionate and Salicylic Acid ointment prices can differ as per the brand, quantity, and local pharmacy or retailer. The approximate price range of the ointment is ₹ 92 to ₹ 270. Individuals must contact a local pharmacy to get the accurate cost. 

Takeaway

Clobetasol Propionate and Salicylic Acid ointment can provide targeted relief for various skin conditions. You can maximise the ointment’s benefits by adhering to proper application techniques. Consistent care and collaboration with your healthcare provider are key to successful treatment outcomes.

Are you looking for a dedicated healthcare partner to receive expert guidance and personalised solutions for your well-being? Our team of professionals at HexaHealth can help you understand treatment options, manage medications, and make informed decisions about your health. We are committed to empowering you on your journey to optimal health.

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Frequently Asked Questions

What are the uses of Clobetasol Propionate and Salicylic Acid ointment?

Clobetasol Propionate and Salicylic Acid ointmentuses include:

  1. Treating various skin conditions like psoriasis and eczema

  2. Reducing inflammation, itching, and scaling

  3. Promoting skin healing

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How effective is Clobetasol Propionate and Salicylic Acid ointment for treating skin conditions?

Clobetasol Propionate and Salicylic Acid ointment is usually extremely effective for treating skin conditions like psoriasis and eczema.

Individuals can generally see improvement within the first two weeks of treatment.

The ointment should be used under medical supervision due to potential side effects.

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What is the price of Clobetasol Propionate and Salicylic Acid ointment?

Clobetasol Propionate and Salicylic Acid ointment prices can vary based on brand, quantity, and retailer.

The price can range from ₹ 92 to ₹ 270. It is advisable to check with local pharmacies or healthcare providers for accurate pricing details.

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Are there any specific benefits of using Clobetasol Propionate and Salicylic Acid ointment?

The use of Clobetasol Propionate and Salicylic Acid ointment offers the following benefits:

  1. Reduces inflammation, itching, and redness

  2. Renews skin

  3. Improves skin texture

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What are the possible side effects of Clobetasol Propionate and Salicylic Acid ointment?

Clobetasol Propionate and Salicylic Acid ointment side effects may include:

  1. Skin irritation

  2. Burning

  3. Itching

  4. Redness 

Prolonged use or excessive application can lead to skin thinning or more severe reactions. It is important to use it under medical guidance and follow instructions carefully.

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Can Clobetasol Propionate and Salicylic Acid ointment be used for acne treatment?

Using Clobetasol Propionate and Salicylic Acid ointment for the face is not recommended.

The ointment is not typically used for acne treatment. It helps in exfoliating the skin and reducing inflammation.

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Is a prescription required to purchase Clobetasol Propionate and Salicylic Acid ointment?

Yes, a prescription is required to purchase Clobetasol Propionate and Salicylic Acid ointment.

Due to potential side effects and interactions, the ointment should be used under medical supervision.

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Can Clobetasol Propionate and Salicylic Acid ointment be used for scalp conditions?

Yes, Clobetasol Propionate and Salicylic Acid ointment can be used for scalp conditions.

It helps reduce scalp swelling, itching, and redness caused by these conditions.

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How long does it take to see results when using Clobetasol Propionate and Salicylic Acid ointment?

Clobetasol Propionate and Salicylic Acid ointment results vary based on the treated condition.

Improvement can be seen within the first two weeks of treatment. If an individual’s skin condition does not improve after two weeks, they should consult their healthcare provider. 

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Will Clobetasol and Salicylic Acid be more effective if taken more than prescribed?

No, using Clobetasol Propionate and Salicylic Acid ointment more than prescribed is ineffective.

Overusing the ointment can lead to adverse effects like skin thinning and increased irritation.

Follow the prescribed dosage and usage instructions for safe and effective treatment.

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What precautions need to be taken while using Clobetasol and Salicylic Acid?

 The precautions that must be taken while using Clobetasol Propionate and Salicylic Acid ointment include:

  1. Follow the prescribed duration 

  2. Avoid prolonged use of the ointment

  3. Avoid tight bandages or dressings on the treated area

  4. Do not apply on open wounds

  5. Use a mild moisturiser to prevent skin dryness

  6. Consult a healthcare provider before using the ointment during pregnancy or breastfeeding  

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Are there any alternatives to Clobetasol Propionate and Salicylic Acid ointment for similar conditions?

Yes, alternatives for certain skin conditions include other topical corticosteroids like hydrocortisone. It is a corticosteroid that reduces pain, itching, and inflammation caused by skin conditions like psoriasis and dermatitis.

Individuals should consult a healthcare provider for suitable alternatives based on their condition and needs.

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What are the instructions for storing and disposing of Clobetasol and Salicylic Acid?

The instructions for storing and disposing of Clobetasol and Salicylic Acid ointment are as follows:

  1. Store the ointment at room temperature, away from heat and sunlight. 

  2. Close the lid tightly and keep it in the original container. 

  3. Keep it out of reach of children and pets. 

  4. Dispose of unused or expired medication. 

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References

All the articles on HexaHealth are supported by verified medically-recognized sources such as; peer-reviewed academic research papers, research institutions, and medical journals. Our medical reviewers also check references of the articles to prioritize accuracy and relevance. Refer to our detailed editorial policy for more information.


  1. Scheinfeld NS, Mikhail M. Common diseases/treatment options: treatment options for psoriasis part 1: topical treatments. Skinmed [Internet]. 2004 [cited 2023 Aug 10];3(4):225–7. link
  2. Srinivas Sidgiddi, Syed, Manjunath Mala Shenoy, Devang Narayan Balraj, Kothari J, Gupta S, et al. Efficacy and Safety of Novel Formulation of Clobetasol Propionate 0.025% Cream in Indian Moderate-to-Severe Psoriasis Patients: Phase-2a, Randomized 3-Arm Study. Dermatology and therapy [Internet]. 2021link
  3. Ali MS. Accelerated Stability Testing of a Clobetasol Propionate Loaded Nanoemulsion as per ICH Guideline. Scientia Pharmaceutica. 2013;81(4):1089–100.link
  4. Guenther LC. Fixed-Dose Combination Therapy for Psoriasis. American Journal of Clinical Dermatology. 2004;5(2):71–7.link

Updated on : 15 December 2023

Reviewer

Dr. Aman Priya Khanna

Dr. Aman Priya Khanna

MBBS, DNB General Surgery, Fellowship in Minimal Access Surgery, FIAGES

12 Years Experience

Dr Aman Priya Khanna is a well-known General Surgeon, Proctologist and Bariatric Surgeon currently associated with HealthFort Clinic, Health First Multispecialty Clinic in Delhi. He has 12 years of experience in General Surgery and worke...View More

Author

Sangeeta Sharma

Sangeeta Sharma

BSc. Biochemistry I MSc. Biochemistry (Oxford College Bangalore)

6 Years Experience

She has extensive experience in content and regulatory writing with reputed organisations like Sun Pharmaceuticals and Innodata. Skilled in SEO and passionate about creating informative and engaging medical conten...View More

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