7 Best Medicines for High SGPT and SGOT Treatment

Written by Hexahealth Care Team, last updated on 8 August 2023| min read
 7 Best Medicines for High SGPT and SGOT Treatment

Quick Summary

  • High SGPT and SGOT are treatable with medication.
  • The right medication can significantly bring down SGPT and SGOT levels.
  • Lifestyle changes can also help manage high SGPT and SGOT levels.

Liver enzymes (SGPT and SGOT) are essential for proper liver function, but when their levels rise, it may indicate liver damage or disease. But is high SGPT and SGOT curable? Fortunately, high SGOT and SGPT levels are treatable. 

With the right medication, a person can significantly bring their levels down and pave their way towards a healthy body. So let's start to discover the best medicine for high SGPT and SGOT along with its side effects and lifestyle changes.

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What are SGOT and SGPT?

Serum Glutamic Pyruvic Transaminase (SGPT) and Serum Glutamic Oxyaloacetic Transaminase (SGOT) are the two main enzymes that are present in the liver cells.

They play a vital role in various metabolic processes in the body such as metabolising of amino acids, the building blocks of proteins.

SGOT is also present in other tissues, such as the heart muscle, while SGPT is mainly found in the liver. 

Normal ranges of SGOT and SGPT levels

  1. SGPT (Alanine Aminotransferase): Under 25 U/L for women and under 33 U/L for men
  2. SGOT (Aspartate Aminotransferase): Under 36 U/L
  3. ALP (Alkaline Phosphatase): Between 20 and 140 U/L

When the liver cells get damaged or injured, these enzymes are released into the blood, causing the levels of SGOT and SGPT to rise in the blood. 

Blood tests are recommended by the physician to measure these enzyme levels. The results of this test can reveal important details about the health of the liver and the presence of any diseases or ailments.

Elevated enzyme levels may indicate acute hepatitis A or B infections, chronic viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), drug-induced hepatotoxicity, or even cancer.

It's important to note that elevated enzyme levels don't always cause symptoms but can be detected through routine blood tests.

If you have concerns about the significance of your SGOT and SGPT results, consult your doctor for further evaluation and the best medicine for high SGPT and SGOT.

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Role of Medicines in SGPT and SGOT Treatment

High SGPT and SGOT levels, which are symptoms of liver damage or dysfunction, can be managed with medication.

The main objective of medications is to promote liver health and address the underlying cause of high liver enzymes. Here are some key points:

  1. Medicines are frequently administered to treat particular liver ailments or diseases that result in high SGPT and SGOT values.

    Antiviral drugs, for instance, may be used to treat viral hepatitis, while drugs for non-alcoholic fatty liver disease (NAFLD) concentrate on controlling problems including obesity, diabetes, and high cholesterol.
  2. Drugs having anti-inflammatory or immunosuppressive characteristics may be administered in cases of liver inflammation.

    These drugs can lessen SGPT and SGOT levels, lessen liver inflammation, and stop future liver damage.
  3. Some drugs are known to have hepatoprotective characteristics which means they aid in preventing liver injury. These drugs may help the liver function, encourage cell regeneration, and lessen oxidative stress on the liver.

Best Medicines for High SGOT and SGPT

Various illnesses, including alcoholic liver disease, liver hepatitis, drug side effects, and fatty liver disease can bring on elevated SGPT and SGOT values. Depending on the underlying cause, different treatment strategies will be used. The following are some examples of drugs frequently used to treat elevated SGPT and SGOT levels:

  1. Hydroxychloroquine: This antimalarial drug is most commonly used to fight malaria-related infections. Is it also used for rheumatoid arthritis and lupus.

    When taken in addition to aspirin or Methotrexate (MTX), hydroxychloroquine has been known to control SGOT and SGPT abnormalities.
  2. Vitamin E Supplements: Vitamin E supplements have been found to help lower elevated enzyme levels when taken regularly over a period of time.

    Vitamin E is an antioxidant in our system, preventing cell damage due to free radicals.
  3. Ursodeoxycholic Acid: UDCA is a secondary bile produced by intestinal bacteria. It comprises hepatoprotective effects, which improve liver functions and reduces SGOT and SGPT levels. 

Prescription drug usage or dietary supplements should always be taken under the guidance of a doctor. Self-medication may have more negative effects than positive.

Ayurvedic Remedies for High SGPT and SGOT Levels

Many substitutive therapies and medications can be taken to control the rising SGPT and SGOT levels. Ayurvedic medicines are among the most effective treatments that work magic on the SGOT and SGPT levels. 

Even though these treatments have been known to be effective, it is essential to seek the expertise of their healthcare provider. Some of the best ayurvedic medicine for high SGPT and SGOT are:

  1. Milk Thistle: One of the most popular ayurvedic herbs for liver support is this one.

    It consists of a flavonoid called silymarin, which has anti-inflammatory and antioxidant properties and guards against liver damage.
  2. Kutki: This is another essential herb used in Ayurveda for safeguarding the liver. It consists of compounds called Kutkin and Picrorhiza that have liver protective effects.

    It also possesses numerous anti-inflammatory and antioxidant qualities.
  3. Turmeric: One of the most common ingredients in Ayurvedic medicine, turmeric consists of a compound called curcumin.

    Continuously using turmeric is highly beneficial for curing high levels of SGOT and SGPT.
  4. Triphala: Triphala combines three ingredients, Amla, Haritaki, and Bibhitaki, potentially benefiting the health condition.

    It supports digestion and liver support significantly.

Side Effects of Medicines for High SGPT and SGOT

Just like most medications for underlying health disorders, medications for SGOT and SGPT can have side effects on a person's overall health. Each person's symptoms will differ based on their unique medical conditions. 

Before taking any medication or treatment for high SGPT and SGOT levels, it's important to be aware of potential side effects.

Here are some commonly reported side effects of medications used for medicines prescribed for elevated SGPT and SGOT tests:

  1. Liver Toxicity: Some drugs may have the potential to cause damage to the liver, resulting in increased SGPT and SGOT levels.

    To make sure the drug is not having any negative effects on the liver, the function of the liver must be regularly monitored.
  2. Gastrointestinal Issues: Sometimes, gastrointestinal adverse effects from medications including nausea, vomiting, diarrhea, or abdominal pain might occur.

    These side effects are often temporary and may disappear with time or with dose modifications.
  3. Allergic Reactions: Certain people may develop adverse allergic reactions to drugs, which can show up as skin rashes, itching, swelling, or breathing difficulties.
  4. Drug Interactions: High SGPT and SGOT level drugs may interact with other medications you are taking, perhaps leading to negative effects or decreasing the effectiveness of either treatment. 
  5. Other Possible Side Effects: Based on certain medications, some patients may also feel certain side effects such as dizziness, headache, fatigue, muscle pain, diarrhea, stomach upset, or changes in blood pressure.

    These side effects may differ from patient to patient.

It's highly important that the dosage instructions for the best medicine for high SGOT and SGPT are followed carefully and any concerning symptoms are reported promptly. 

Precautions for Medicines for High SGPT and SGOT

Elevated levels of SGOT and SGPT in the blood indicate liver damage or injury. Besides making serious lifestyle changes and avoiding medicines that can boost the normal SGOT and SGPT levels, a person must take the following precautions. These are : 

  1. Medical Expertise: For any person suffering from fluctuations in their normal range of SGOT, and SGPT levels, it is crucial to consult their healthcare provider before starting any new medicine.

    Not only can you take the medication after their approval, but in many cases, the doctors also monitor the condition of the liver for changes.
  2. Avoid Hepatotoxic Medications: One must strictly put control over taking over-the-counter pain relievers.

    These include acetaminophen or ibuprofen and medicines that contain hepatotoxic compositions.
  3. Alternative Therapies: There are many alternative therapies available, like acupuncture massages, home remedies, herbal remedies, etc, which have been known to do wonders to control and manage the SGOT and SGPT.

    These must surely be tried to reduce the negative effects of the medications.
  4. Monitor the Liver Functions: Regular monitoring of the SGOT and SGPT levels are essential to ensure no further damage or rise in the values.

    One must stay in close touch with their healthcare provider and inform them of new signs and symptoms.

Lifestyle Changes to Lower SGPT and SGOT Levels

Lifestyle changes have been known to be highly beneficial for not just one but all body parts. Those who incorporate permanent healthy changes in their lifestyle are sure to see the change in their health and body by leaps and bounds. 

The following are some tips when incorporated with the best medicine for high SGPT and SGOT, can lead to effective results:

  1. Maintain a Healthy Weight: Obesity has been known to be one of the primary causes of high liver enzymes.

    Losing weight can help reduce inflammation and stress on your liver, thus acting as a treatment for high  SGOT and SGPT levels.
  2. Exercise Regularly: Making regular exercise a part of your everyday routine helps in maintaining a healthy weight and also improves blood flow to the liver, which reduces the risk of developing fatty liver disease.
  3. Reduce Alcohol Intake: Excessive alcohol consumption damages liver cells, causing elevated enzyme levels.

    Limiting or eliminating your alcohol intake is crucial for reducing both SGOT and SGPT levels.
  4. Quit Smoking: Smoking increases oxidative stress on the body, including the liver.

    It's highly recommended to quit smoking if you want to see a reduction in your enzyme levels.
  5. Follow a Balanced Diet Plan: A well-balanced diet comprising fresh fruits, vegetables, whole grains, and lean protein sources like fish or poultry can be beneficial in keeping your enzyme values under control.

By implementing these simple yet effective lifestyle modifications with the best medicine for high SGPT and SGOT into your daily routine, you may notice a significant improvement in lowered SGPT and SGOT levels and overall improved health status.


High SGOT and SGPT levels can indicate liver damage or disease. Identifying the underlying cause of elevated SGOT and SGPT levels is important to treat the condition properly. The best medicine for high SGPT and SGOT treatment is highly effective in treating liver disorders.

However, it's important to remember that medication alone may not be enough. Lifestyle changes like a healthy diet consisting of low-fat foods and regular exercise can help improve liver health and lower SGOT/SGPT levels. 

Hexahealth is a name that has been closely synonymous with the leading and the most reliable names in the health and medical industry. As a team of experts, we are committed to providing useful, accurate, and foolproof information to make every medical journey easy.

We are a one-stop destination for those struggling with health-related issues and searching for the best aid available. To find out more, get in touch with us today. 

Suggested Reads

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Difference Between SGPT and SGOT Diet for High SGPT and SGOT levels in Pregnancy in Hindi
High SGPT SGOT Side Effect During Pregnancy in Hindi How to Control SGPT in Hindi

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Frequently Asked Questions

The best medicine for high SGPT and SGOT levels depends on the underlying cause. 

  1. For example, if the cause is a disease, such as liver hepatitis, treatment may involve antiviral medication or immune system modulators. If the cause is medication-related, stopping or changing the medication may be necessary.
  2. There is no specific medication to lower SGPT and SGOT levels directly, but some medications, such as Ursodeoxycholic acid, may help in certain cases. It is essential to consult a doctor to determine the best course of treatment for elevated SGPT and SGOT levels.

If you are wondering if high SGPT and SGOT are curable, you must know that high SGPT and SGOT levels are not diseases but indicators of liver damage. The root cause must be found and addressed.

Depending on the circumstance, the liver enzymes can return to normal levels with the right care.

SGPT (serum glutamate pyruvate transaminase) and SGOT (serum glutamic oxaloacetic transaminase) are two enzymes present in the liver and other organs. 

SGPT (Serum Glutamate Pyruvate Transaminase) and SGOT (Serum Glutamic Oxaloacetic Transaminase) are enzymes found in the liver and other organs. 

  1. They play a crucial role in the metabolism of amino acids and transfer amino groups from one molecule to another.
  2. Elevated levels of SGPT and SGOT usually indicate liver damage or dysfunction. They are released into the bloodstream when liver cells are damaged or destroyed. 

Therefore, monitoring the levels of these enzymes can provide useful information about the health and function of the liver.

There are several reasons why SGPT and SGOT levels may be elevated, including: 

  1. Liver diseases, such as hepatitis (viral or autoimmune), liver cirrhosis, and fatty liver disease
  2. Excessive alcohol consumption
  3. Certain medications, such as statins, antibiotics, and chemotherapy drugs
  4. Obesity
  5. Other conditions, such as pancreatitis, gallbladder disease, and muscle damage

 Yes, making certain lifestyle changes can help lower SGPT and SGOT levels, such as:

  1. Eating a healthy, low-fat, high-fiber diet 
  2. Regular exercise to maintain a healthy weight and relieve stress
  3. Avoiding toxins and substances that can harm the liver.
  4. Avoiding alcohol or limiting alcohol consumption
  5. Avoiding unnecessary medications and discussing any prescribed medications with a doctor
The time SGPT and SGOT levels take to normal after starting treatment depends on the underlying cause of elevated levels. In some cases, the duration may vary from several weeks or months, while in others, it may take longer.

The potential side effects of medications used to treat high SGPT and SGOT levels depend on the medication used. Some common side effects of medications used to treat liver diseases include nausea, diarrhea, fatigue, and headache.

Before beginning any medicine, discussing potential side effects with the doctor is critical.

No scientific proof supports the use of natural remedies or supplements in lowering SGPT and SGOT levels. However, some supplements, such as milk thistle and turmeric, have been studied for their potential to protect the liver and promote liver health.

While these supplements may have some benefits, it is essential to consult a doctor before taking them. They can interact with other medications and cause side effects in some people.

In many cases, high SGPT and SGOT levels can be reversed with proper treatment, especially if the underlying cause can be identified and addressed early.

However, if severe liver damage or cirrhosis has developed, SGPT and SGOT levels may remain elevated even with treatment.

The frequency of monitoring SGPT and SGOT levels during treatment depends on the underlying cause and the severity of the liver damage. Doctors may monitor levels every few weeks to months to assess treatment effectiveness and adjust the treatment plan as needed.

High SGPT and SGOT levels can clearly indicate a more serious liver condition, such as hepatitis or cirrhosis. If not treated in time, these conditions may lead to liver failure, which can be life-threatening.

Therefore, one must seek medical attention if SGPT and SGOT levels are consistently elevated or if other symptoms, such as jaundice, abdominal pain, or fatigue, are present.


All the articles on HexaHealth are supported by verified medically-recognized sources such as; peer-reviewed academic research papers, research institutions, and medical journals. Our medical reviewers also check references of the articles to prioritize accuracy and relevance. Refer to our detailed editorial policy for more information.

  1. 1.Fries JF, Singh G, Lenert L, Furst DE. Aspirin, hydroxychloroquine, and hepatic enzyme abnormalities with methotrexate in rheumatoid arthritis. Arthritis & Rheumatism. 1990 Nov;33(11):1611–9.link
  2. Elevated liver enzymes Causes [Internet]. Mayo Clinic. 2018.link
  3. Fries JF, Singh G, Lenert L, Furst DE. Aspirin, hydroxychloroquine, and hepatic enzyme abnormalities with methotrexate in rheumatoid arthritis. Arthritis & Rheumatism. 1990 Nov;33(11):1611–9.link
  4. Medications and the Liver - American College of Gastroenterology [Internet]. American College of Gastroenterology. 2011.link

Updated on : 8 August 2023

Disclaimer: The information provided here is for educational and learning purposes only. It doesn't cover every medical condition and might not be relevant to your personal situation. This information isn't medical advice, isn't meant for diagnosing any condition, and shouldn't replace talking to a certified medical or healthcare professional.
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