SGPT and SGOT Levels in Jaundice
SGOT or AST (aspartate aminotransferase) and SGPT or ALT (alanine aminotransferase) are enzymes mainly produced by the liver cells. When the liver or its cells are damaged due to any disease, SGOT and SGPT stored in the liver cells get released in the blood. This is why, when someone suffers from liver disease, their liver function test report may show elevated liver enzymes. Therefore, the level of these enzymes in the blood is an indicator of liver health. Jaundice is again a condition that indicates that there may be something wrong with the liver.
Jaundice occurs due to the increased production of bilirubin - a yellow pigment that forms during the breakdown of red blood cells. When total bilirubin is more than 1.2 mg/dL, it may indicate jaundice. So, SGOT and SGPT levels are unrelated to jaundice but may indicate a liver disease that has caused jaundice.
To understand the significance of SGOT and SGPT levels in jaundice, it is important to first know about this condition and its underlying causes.
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What Is Jaundice?
Bilirubin is a yellow-orange pigment produced when the liver breaks down haemoglobin. It is excreted in bile through the liver and is eventually passed out of the body.
But if there is damage in the liver, it fails to filter it from the bloodstream, leading to the buildup of bilirubin that gradually starts reflecting in the colour of the skin and sclera (white of the eyes).
How Is It Caused?
SGPT and SGOT levels in jaundice can be indicators of the following underlying conditions:-
- Hepatitis - Inflammation in the liver is known as hepatitis. In most cases, this condition is caused due to a virus. However, certain medications, autoimmune disorders, and heavy alcohol can also cause hepatitis. The inflammatory condition of the liver can affect its normal functioning. If this condition remains untreated for a long time, it may damage the liver and cause jaundice.
- Alcohol-Induced Liver Disease - When a person drinks high amounts of alcohol that his or her liver cannot process, it can lead to severe damage. Alcohol-induced liver diseases can progress to three stages over time, depending on the amount of alcohol consumption.
- Fatty Liver - Anyone who drinks excess alcohol may experience a buildup of fats inside the liver cells leading to fatty liver. It is the most common alcohol-induced liver disease.
- Alcoholic Hepatitis - It occurs when there is acute liver inflammation due to heavy alcohol use for many years. This condition may lead to the death of the liver cells, and it may even cause permanent scarring.
- Alcoholic Cirrhosis - In this stage, the liver is significantly scarred and is generally not reversible. However, avoiding alcohol consumption can prevent further damage.
- Autoimmune Hepatitis - This condition occurs when the body’s immune system attacks healthy liver cells by mistake. It can also seriously damage the liver resulting in jaundice.
- Non-Alcoholic Fatty Liver Disease - People who aren’t heavy drinkers may also have fatty liver disease. Those with obesity and diabetes are at an increased risk of this disease.
- Blockage in the thin tubes (bile ducts) that carry bile from the liver to the gall bladder and eventually to the small intestines.
- Pancreatic cancer - It can lead to blockage in the bile ducts resulting in jaundice.
- The use of medications, such as acetaminophen, birth control pills, and steroids, may also result in liver disease.
- Rare genetic metabolic defects also sometimes affect the normal functioning of the liver.
Symptoms
- Change in skin colour
- Dark coloured urine
- Fever
- Chills
- Abdominal pain
- Chronic hepatitis - inflammation of the liver
- Acute hepatitis A, B, or C
- Inflammation of the joints
- Pyoderma Gangrenosum - a condition that causes large and painful sores on the skin
How Is It Diagnosed?
- Bilirubin Tests: To measure the level of bilirubin present in your blood.
- Complete Blood Count (CBC) Test: To evaluate the level of red blood cells, white blood cells, and platelets in your blood.
- Hepatitis A, B, or C Tests: To check the presence of a liver infection.
SGPT and SGOT Levels in Jaundice
It has become clear that SGOT and SGPT levels in the blood are not due to jaundice. So, the type and severity of the symptoms of jaundice depend on the underlying cause of liver damage rather than the levels of SGOT and SGPT.
Conclusion
Usually, jaundice doesn’t bear any life-threatening risks and can be easily managed with medications. But if high levels of SGPT and SGOT in jaundice are detected, you should consult a doctor immediately for a further checkup to diagnose the underlying cause in time.
In case you want to ask any queries or doubts related to your medical condition, our experts at Hexa Health can help you find the right solution. The Hexa Health team includes well-trained and skilled professionals who can provide accurate guidance regarding your disease along with proper treatment advice. So, connect with a Hexa Health expert today!
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Frequently Asked Questions
What is Jaundice?
What is the level of SGPT and SGOT in jaundice?
What causes high SGPT and high SGOT?
- Obesity
- Excessive alcohol consumption
- Acute viral hepatitis
- Autoimmune disorders
- Heartattack
- Diabetes
- Muscle injuries
Does high SGOT and SGPT levels indicate jaundice?
What is the normal point of jaundice?
The normal level of bilirubin is:-
- Direct or conjugated bilirubin: less than 0.3 mg/dL
- Total bilirubin: 0.1 to 1.2 mg/dL
What may happen if SGOT and SGPT levels do not come down?
- Shortness of breath
- Jaundice
- Easy bruising and excessive bleeding
- Weakness and tiredness
- Nausea
- Swelling in the legs and feet
Updated on : 6 September 2023
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Dr. Aman Priya Khanna
MBBS, DNB General Surgery, Fellowship in Minimal Access Surgery, FIAGES
12 Years Experience
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