Liver Biopsy - Procedure, Indications, Purpose & Recovery

Liver Biopsy

Treatment Duration

clock

15 Minutes

------ To ------

30 Minutes

Treatment Cost

rupee

3,000

------ To ------

15,000

WhatsApp Expert
Liver Biopsy

Book Appointment for Liver Biopsy

According to Singhai et al., 2023, 43.6% of the study population in India was diagnosed with non-alcoholic fatty liver disease. This underscores the urgent need for effective diagnostic measures. A liver biopsy is one such method for evaluating various liver conditions. It provides essential information that can influence treatment plans and patient outcomes.

The doctor uses a specialised liver biopsy needle to obtain clear diagnostic samples for precise medical evaluations. But what conditions can be diagnosed with this procedure? Are there any risks that one should be aware of? Keep reading to find out.

Procedure Name 

Liver Biopsy 

Conditions Diagnosed 

Fatty liver disease, liver cirrhosis, liver cancer 

Benefits of the Procedure 

Minimally invasive, outpatient procedure, low risk of complications 

Treated By 

Gastroenterologists or hepatologists


You can check Liver Biopsy Cost here.

What is a liver biopsy?

A liver biopsy is a procedure in which a small liver tissue sample is removed for examination under a microscope. It helps diagnose and evaluate the extent of liver disease, inflammation, fibrosis, or cancerous cells. 

The test can be performed using different techniques, such as: 

  1. Percutaneous: Also known as a needle biopsy, this is the most common type. It involves inserting the needle through the skin.

  2. Transjugular: In this method, the sample is obtained by inserting a catheter into the jugular vein in the neck (which carries blood from the head to the upper chest) and the liver. It is primarily used for patients with bleeding disorders.

  3. Laparoscopic: It uses a laparoscope and surgical instruments to collect a tissue sample.

Anatomy and Physiology of the Liver

The liver is a large, reddish-brown organ in the upper-right portion of the abdomen, just below the diaphragm. It is divided into two primary lobes; a larger right lobe and a smaller left lobe. The liver has over 500 essential functions in the body. Some of these include the following: 

  1. Bile Production: The liver cells, or hepatocytes, produce bile, which is collected by a system of ducts that flow into the common hepatic duct. It transports bile to the gallbladder and duodenum (the first part of the small intestine).

  2. Blood Supply: The liver has a unique blood supply from two sources. The hepatic artery provides oxygen-rich blood, while the hepatic portal vein carries nutrient-rich blood.


Conditions Diagnosed with Liver Biopsy

Liver biopsy offers valuable information about the type and extent of liver damage. It is crucial for accurate diagnosis and optimal treatment planning. Conditions that can be diagnosed using this procedure include: 

  1. Non-alcoholic Fatty Liver Disease (NAFLD): Excess fat builds up in the liver, often in overweight and obese people 

  2. Liver Cirrhosis: Excessive scarring of the liver due to hepatitis, chronic alcoholism, etc. 

  3. Autoimmune Hepatitis: The immune system of the body attacks liver cells, causing inflammation 

  4. Hepatitis B and C: Swelling and irritation of the liver caused by viral infections 

  5. Primary Biliary Cholangitis: Chronic inflammation in the bile ducts

Need for Liver Biopsy

A doctor may recommend this procedure if a patient gets irregular results on other liver tests. It is primarily used to diagnose liver diseases by examining tissue directly under a microscope. The reasons for liver biopsy may be as follows: 

  1. Diagnosing liver conditions that cannot be detected with blood tests and imaging studies 

  2. Obtaining a tissue sample to evaluate an irregularity found by an imaging test 

  3. Assessing the severity and stage of liver disease 

  4. Guiding treatment plans based on the results from a biopsy 

  5. Monitoring the progress of treatment for liver disease

Expert Doctors

Radiation Oncology

14+ Years

Experience

98%

Recommended

Gastroenterology, Hepatology and Endoscopy

42+ Years

Experience

98%

Recommended

NABH Accredited Hospitals

Health Care Clinic, Kavi Nagar
JCI
NABH

Health Care Clinic, Kavi Nagar

4.8/5(88 Ratings)
Kavi Nagar, Ghaziabad
Dharamshila Narayana Superspeciality Hospital
JCI
NABH

Dharamshila Narayana Superspeciality Hospital

4.9/5(97 Ratings)
Vasundhara Enclave, Delhi
Calculate Surgery Cost
Calculate Insurance Coverage

Before and on the Day of the Liver Biopsy

Patients scheduled for a liver biopsy receive detailed instructions from their hepatologist or gastroenterologist to ensure the procedure proceeds smoothly. The guidelines provided before and on the day of the biopsy include:

Before Liver Biopsy

Individuals have an initial consultation with their doctor to discuss any questions and address concerns. The medical team explains the biopsy procedure, how it’s performed, and what to expect during and after the process. Here’s what one can anticipate during this visit:

Parameters 

Prerequisites 

Pre-op Assessments 

  1. Physical exam 

  2. Blood tests 

Risk Evaluation 

  1. Allergies 

  2. Risks vs benefits 

Restrictions 

Blood thinners and pain relievers for one week before the test

Anaesthesia Selection 

  1. Local (for percutaneous and transjugular)

  2. General (for laparoscopic) 

Fasting 

6-8 hours before the procedure 

On the Day of the Liver Biopsy

On the day of the procedure, patients should arrange for someone to drive them home after the biopsy. Once they reach the hospital, the following is what usually takes place: 

Parameters 

Prerequisites 

Consent 

Mandatory 

Surgical Preparation 

  1. Changing into a hospital gown 

  2. Marking the area for the biopsy 

Physical Evaluation 

Vitals check-up (breathing, heart rate, temperature, etc.)

IV Line 

Yes, for fluids and medications

Patient Position 

  1. Lying on the back with right hand above the head (for percutaneous)

  2. Lying on the back (for transjugular and laparoscopic)

Liver Biopsy Procedure

A liver biopsy test is done in a hospital or outpatient centre. The duration depends on the type of procedure performed. While a percutaneous biopsy takes 15 to 30 minutes, a transjugular biopsy takes 30 to 60 minutes. The steps are as follows: 

  1. Anaesthesia: For percutaneous and transjugular biopsy, the surgeon inserts local anaesthesia into the site to numb the area. Patients receive general anaesthesia for laparoscopic biopsy. 

  2. Final Procedure: Patients are asked to hold their breath as a liver biopsy needle is inserted to extract a tissue sample. However, the exact steps can differ according to the type of test: 

    1. Percutaneous Biopsy: One small incision is made in the skin over the liver. The biopsy needle is inserted through this incision directly into the liver. This is often guided by radiology images to ensure accurate placement of the needle.

    2. Transjugular Biopsy: A catheter is inserted into the jugular vein in the neck and guided through the veins into the liver. The biopsy needle passes through the catheter.

    3. Laparoscopic Biopsy: Small cuts are made in the abdomen, and a laparoscope and other instruments are inserted to take a tissue sample. 

  3. Closure: After the sample is taken, the cut is closed with stitches for laparoscopic biopsy. In the transjugular test, the surgical site is covered with a bandage. The patient is positioned on the right side to apply pressure on the liver and prevent bleeding. 

After the biopsy sample is collected, it is sent to a pathology lab. A pathologist examines this tissue under a microscope. 

After Liver Biopsy and Recovery

After the procedure, it is normal to experience soreness at the needle insertion site for up to a week. Patients should follow their doctor’s guidelines to ensure a smooth recovery both in the hospital and at home. 

In-Hospital Recovery

After a liver biopsy procedure, patients are moved to a recovery room, where the nursing staff monitors their vital signs, such as breathing, blood pressure, and temperature. Patients must rest in the recovery room for two to four hours. Once their condition stabilises, they can return home on the same day. 

At-Home Recovery

Recovery after a liver biopsy is generally quick. Most individuals can resume work and normal activities the next day of the procedure. Some recovery guidelines to be followed after the test include: 

  1. Rest for 24 hours.  

  2. Leave the bandage in place until the next day.

  3. Take prescribed medications to manage pain. 

  4. Avoid heavy lifting and intense activity for up to one week. 

Follow-up Appointment

The first follow-up appointment is scheduled 1-2 weeks after the liver biopsy. During this visit, the doctor checks the incisions and looks for signs of complications like infection or excessive bleeding. The hepatologist also discusses the biopsy results, explaining what was found in the liver tissue sample. 

The liver biopsy report is available within a week or two after the procedure. Normal results indicate that the patient’s liver tissue is normal. However, if the biopsy shows abnormal results, it may indicate inflammation and fibrosis, fatty liver, Cirrhosis, etc.

The results from a liver biopsy test help guide the course of treatment.

Benefits of Liver Biopsy

A liver biopsy provides precise and crucial information, making it an indispensable procedure in hepatology. According to a study by Szymczak et al., the overall success rate of percutaneous liver biopsy is 95.3%. The benefits offered by the test are as follows: 

  1. Minimally Invasive: A liver biopsy is typically performed using small incisions or needle punctures. This reduces the risk of complications, minimises pain, and leads to a quicker recovery than more invasive surgical procedures.

  2. Targeted Sampling: The procedure allows for direct sampling of liver tissue from specific areas of concern identified through imaging studies. This increases the accuracy of the diagnosis.

  3. Low Complication Rate: All surgical procedures carry some risk. However, liver biopsies have a relatively low risk of serious complications (1%) like bleeding and infection.

  4. Outpatient Procedure: Patients do not require an overnight hospital stay. This helps reduce healthcare costs associated with inpatient care. Moreover, it allows them to return to normal activities quickly.

Risks and Complications of Liver Biopsy

Liver biopsies are generally considered safe when performed by skilled specialists. The overall rate of serious complications after the test is about 1%. However, like any surgical procedure, it has certain risks, which include the following: 

  1. Pain: Mild discomfort at the biopsy site is the most common complication that occurs in 84% of cases.

  2. Bleeding: It occurs in approximately one out of every 500 liver biopsies. More severe bleeding is rare, occurring in one out of every 2,500-10,000 liver biopsies. However, in cases of severe bleeding, blood transfusion or surgery may be necessary. 

  3. Infection: There is a small risk of bacteria entering the abdominal cavity or bloodstream.

  4. Injury to Other Organs: Although rare, the liver biopsy needle may accidentally damage other nearby organs, such as the gallbladder or lungs, during the procedure.

Since the transjugular test involves inserting a catheter down a large vein in the neck, it involves some additional risks, including: 

  1. Haematoma (a collection of blood at the site of biopsy)

  2. Temporary voice changes

  3. Damage to facial nerves, causing short-term issues like drooping eyelid 

  4. Pneumothorax (punctured lung)

When to consult a doctor?

After undergoing a liver biopsy, patients should monitor their health for any signs of complications. They should immediately contact their doctor if they experience the following within 72 hours of the test:

  1. A fever higher than 101 F or chills

  2. Dizziness

  3. Trouble breathing or chest pain

  4. Abdominal swelling or intense pain

  5. Redness, tenderness, or severe pain at the biopsy site or in the chest, abdomen, or shoulder

Risks of Delaying a Liver Biopsy

A liver biopsy is a gold standard diagnostic test for liver diseases. Delaying it can lead to several complications, particularly if underlying liver conditions are left undiagnosed or untreated. The following are the potential risks associated with postponing this vital test:

  1. Progression of Liver Disease: Without a timely diagnosis, liver diseases such as fibrosis, cirrhosis, or hepatitis can progress to more severe liver damage or liver failure.

  2. Increased Health Complications: A delay in treatment can lead to complications like ascites (fluid buildup in the abdomen) and hepatic encephalopathy (brain dysfunction due to advanced liver disease). These are severe and potentially life-threatening.

  3. Worsening of Symptoms: If the diagnosis and treatment are delayed, jaundice, fatigue, and abdominal pain may worsen. This can significantly affect an individual’s quality of life.

Cost of Liver Biopsy 

The liver biopsy cost in India can vary among individuals based on several factors. The price can range between ₹ 3,000 and ₹ 15,000. The average expense is ₹ 10,000. 

Procedure Name 

Estimated Cost Range 

Liver Biopsy 

₹ 3,000 to ₹ 15,000

Note: This cost is approximate. Please consult HexaHealth experts for accurate and current pricing information. 

Factors that affect the cost of liver biopsy include: 

  1. Type of Biopsy: The method used for the liver biopsy can affect cost. Laparoscopic biopsies tend to be more expensive due to the need for general anaesthesia and complex surgical techniques.

  2. Healthcare Facility: Prices can vary significantly depending on whether the procedure is performed in a hospital or an outpatient surgery centre. Hospitals are costlier due to the expenses associated with more comprehensive facilities.

  3. Location: Expenditure is higher in metropolitan cities than in smaller towns due to differences in cost of living and availability of specialised care. 

  4. Surgeon’s Reputation: Experienced specialists may charge more for performing a liver biopsy. 

  5. Insurance: The extent of health insurance coverage can significantly impact the patient’s out-of-pocket expenses. Some policies may cover the full cost, while others cover a portion.

Takeaway

A liver biopsy is a vital diagnostic tool that provides invaluable insights into liver health. By obtaining a small sample of liver tissue, this procedure allows doctors to tailor treatment to individual patient needs. Timely and accurate biopsies can significantly enhance patient outcomes.

At HexaHealth, our medical professionals are well-versed in the latest liver biopsy indications and techniques. We support patients throughout the process, from initial consultation to post-procedure care. So what are you waiting for? Contact us today and take a step towards your liver health.

Frequently Asked Questions (FAQ)

A liver biopsy is a diagnostic procedure that involves removing a tissue sample for microscopic examination. This test helps diagnose liver diseases, assess liver damage, and guide treatment decisions.

WhatsApp

The test offers crucial information on liver diseases. The reasons for liver biopsy may include the following: 

  1. Evaluate the extent of liver damage 

  2. Monitor disease progression 

  3. Assess the effectiveness of a treatment plan for liver diseases

WhatsApp

 There are three primary types of liver biopsies based on the method of accessing the liver tissue. These types include: 

  1. Percutaneous biopsy (through the skin)

  2. Transjugular biopsy (using a vein in the neck)

  3. Laparoscopic biopsy (through small abdominal incisions)

WhatsApp

 A liver biopsy is done under local or general anaesthesia depending on the type of test (percutaneous, transjugular, or laparoscopic). While the exact procedure depends on the type, the general steps are as follows: 

  1. The liver biopsy needle is inserted through the small incisions or the vein in the neck. 

  2. A tissue sample is extracted. 

  3. The needle is removed, and the incision is closed.

WhatsApp

A liver biopsy is generally a safe procedure with approximately 1% risk of serious complications. However, though rare, it carries some serious risks like bleeding and infection, which can be significant when they occur. 

WhatsApp

The duration of the liver biopsy varies depending on the type of the test. A percutaneous biopsy generally takes 15 to 30 minutes to complete. On the other hand, a transjugular biopsy takes about 30 to 60 minutes. 

WhatsApp

The liver biopsy cost can vary widely, typically ranging from ₹ 3,000 to ₹ 15,000. It depends on geographic location, the specific type of biopsy performed, and whether it is covered by health insurance. Patients should consult HexaHealth experts for accurate prices.

WhatsApp

Recovery from a liver biopsy usually involves two to four hours of post-procedure monitoring at the hospital. Most patients are able to return to normal activities the next day. However, strenuous activity should be avoided for about a week.

WhatsApp

Liver biopsy results help diagnose the specific condition and guide treatment decisions. It can indicate the presence and extent of liver diseases such as: 

  1. Fibrosis

  2. Cirrhosis

  3. Fatty liver

  4. Hepatitis

  5. Cancer

WhatsApp

Liver biopsies are highly accurate in diagnosing liver conditions. According to a study by Ishikawa et al., 2022, a transjugular liver biopsy had a 100% success rate in diagnosing the cause of acute liver failure.

WhatsApp

Complications after liver biopsy are rare. However, like other surgical procedures, they can occur and may include the following: 

  1. Pain at the biopsy site 

  2. Bleeding 

  3. Injury to the surrounding organs 

  4. Infection

WhatsApp

Yes, a liver biopsy can detect liver cancer by examining a tissue sample under a microscope to identify cancerous cells. It provides information on the type, stage, and aggressiveness of the cancer.

WhatsApp

The frequency of liver biopsies depends on the specific liver condition being monitored, its progression, and the patient’s response to treatment. For patients with mild liver disease and no comorbidities, waiting at least 4-5 years between biopsies can be effective. It helps detect significant changes in the stage of fibrosis.

WhatsApp

Yes, various alternative tests to a liver biopsy are available. These include: 

  1. Imaging techniques like ultrasound, MRI, and CT scans 

  2. FibroScan 

  3. Liver function tests

WhatsApp

After a liver biopsy test, following post-operative precautions are important for a smooth recovery. These may include the following: 

  1. Rest for the next day. 

  2. Take prescribed pain medications. 

  3. Avoid strenuous activities for a week. 

  4. Monitor the biopsy site for signs of infection.

WhatsApp

The liver biopsy report is available within two weeks. The doctor schedules a follow-up visit to discuss the results with the patient. 

WhatsApp

Yes, there is a small risk of liver biopsy and cancer spread specific to hepatocellular carcinoma (HCC). If a biopsy is performed on a liver with cancer, the malignant cells can pass through the needle and spread to other parts. 

WhatsApp

The liver does not grow back the tissue removed during a biopsy, but it has a remarkable ability to regenerate. The remaining liver tissue can grow and recompensate to maintain liver function.

WhatsApp

Although liver biopsy procedure is the gold standard for diagnosing fatty liver, it may not always be necessary. Imaging tests like ultrasound, CT scan, and MRI can help diagnose fat. 

WhatsApp

Diagnosis of liver cancer does not always need a biopsy. It can sometimes be diagnosed using imaging tests like  CT scans and MRI.

WhatsApp

References

All the articles on HexaHealth are supported by verified medically-recognized sources such as; peer-reviewed academic research papers, research institutions, and medical journals. Our medical reviewers also check references of the articles to prioritize accuracy and relevance. Refer to our detailed editorial policy for more information.


  1. Singhai A, Yadav V, Joshi R, Malik R, T SB, Kamle S. Prevalence, Metabolic Profile, and Associated Risk Factors of Non-alcoholic Fatty Liver Disease in an Adult Population of India. Cureus. 2023 Jan 19;link
  2. Johns Hopkins Medicine. Liver: Anatomy and Functions [Internet]. Johns Hopkins Medicine. 2023. link
  3. Krans B. Liver Biopsy [Internet]. Healthline. Healthline Media; 2012. link
  4. Mayo Clinic. Liver biopsy - Mayo Clinic [Internet]. Mayoclinic.org. 2018. link
  5. What Is a Liver Biopsy? [Internet]. Cleveland Clinic. 2023.link
  6. Liver Biopsy [Internet]. www.hopkinsmedicine.org. link
  7. National Institute of Diabetes and Digestive and Kidney Diseases. Liver Biopsy | NIDDK [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases. 2020. link
  8. Liver Biopsy [Internet]. www.nationwidechildrens.org. [cited 2024 May 4]. link
  9. Liver biopsy results: How long do they take? [Internet]. www.medicalnewstoday.com. 2022 [cited 2024 May 4].link
  10. Liver biopsy Information | Mount Sinai - New York [Internet]. Mount Sinai Health System.link
  11. Szymczak A, Simon K, Małgorzata Inglot, Andrzej Gładysz. Safety and Effectiveness of Blind Percutaneous Liver Biopsy: Analysis of 1412 Procedures. 2012 Jan 1; link
  12. Pandey N, Hoilat GJ, John S. Liver Biopsy [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2020. link
  13. https://www.facebook.com/WebMD. Liver Biopsy [Internet]. WebMD. WebMD; 2004. link
  14. Mayo Clinic. Liver disease [Internet]. Mayo Clinic. 2018.link
  15. Complications of Liver Disease [Internet]. American Liver Foundation. link
  16. How Often Should Biopsy Be Performed? [Internet]. www.natap.org. [cited 2024 May 4]. link
  17. Liver biopsy [Internet]. www.cancerresearchuk.org. link
  18. Finn RS. The Role of Liver Biopsy in Hepatocellular Carcinoma. Gastroenterology & hepatology [Internet]. 2016;12(10):628–30.link
  19. Joy D, Thava VR, Scott BB. Diagnosis of fatty liver disease. European Journal of Gastroenterology & Hepatology. 2003 May;15(5):539–43.link
  20. Liver Cancer Diagnosis - NCI [Internet]. www.cancer.gov. 2022 [cited 2024 May 4]. link

Reviewer

Dr. Aman Priya Khanna

Dr. Aman Priya Khanna

MBBS, DNB General Surgery, Fellowship in Minimal Access Surgery, FIAGES

12 Years Experience

Dr Aman Priya Khanna is a well-known General Surgeon, Proctologist and Bariatric Surgeon currently associated with HealthFort Clinic, Health First Multispecialty Clinic in Delhi. He has 12 years of experience in General Surgery and worke...View More

Author

Sangeeta Sharma

Sangeeta Sharma

BSc. Biochemistry I MSc. Biochemistry (Oxford College Bangalore)

6 Years Experience

She has extensive experience in content and regulatory writing with reputed organisations like Sun Pharmaceuticals and Innodata. Skilled in SEO and passionate about creating informative and engaging medical conten...View More

Book Appointment for Liver Biopsy

get the app
get the app