Bone Marrow Transplant Donor: Age Criteria, Risks, Recovery

Medically Reviewed by Dr. Aman Priya Khanna
Written by Sangeeta Sharma, last updated on 17 July 2023
Bone Marrow Transplant Donor: Age Criteria, Risks, Recovery

A bone marrow transplant is a critical procedure that offers hope to individuals battling cancer, blood disorders, and genetic diseases. As a donor, one has the incredible opportunity to provide healthy stem cells to those in need.

While the risks associated with donation are generally low. The eligibility for donation depends on individual factors, including medical conditions and lifestyle. Keep reading this article to learn more about how to donate bone marrow.

What is Bone Marrow Transplant?

A bone marrow transplant is a medical procedure that replaces damaged bone marrow. The bone marrow is a soft, fatty substance found inside our bones. It produces important blood components, including red blood cells, white blood cells, and platelets.

Healthy blood stem cells are implanted into the body's bone marrow during a bone marrow transplant. These stem cells can develop into different types of blood cells. These also help the body create enough red blood cells, white blood cells, and platelets.

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Types of Donors in Bone Marrow Transplants

There are two types of donors in bone marrow transplants.  They play a crucial role in providing life-saving stem cells to needy patients.

  1. Related Donor: A related donor is a recipient's family member, such as a sibling or parent. They share a genetic connection with the recipient, which increases the likelihood of a close match for the recipient's tissue type. 

    Having a related donor can be advantageous as it often results in better outcomes. It also reduces the risk of complications during the transplantation process. Family members are typically the first individuals considered potential donors for bone marrow transplants.
  1. Unrelated Donor: An unrelated donor is not biologically related to the recipient but is compatible with their tissue type. Donors are identified through registries that maintain a database of volunteers willing to donate their bone marrow or stem cells.

    Unrelated donors are matched with recipients based on their compatibility, which helps reduce the risk of rejection and complications after the transplant.

Who Can Donate?

The eligibility criteria for bone marrow donation may vary. Individuals in good health and compatible tissue types are considered potential donors.

  1. Healthy Individuals: Those in good health and meeting the necessary medical criteria can be potential bone marrow donors.

  1. Age Requirement: Typically, individuals between the ages of 18 and 60 are eligible to donate bone marrow. However, age restrictions may vary based on specific transplant centers or organizations.

  1. Compatibility: Donors must have a compatible tissue type with the recipient. The compatibility is determined through human leukocyte antigen (HLA) matching.

Who Cannot Donate Bone Marrow?

This list needs to be more comprehensive, and other medical conditions or factors can disqualify someone from donating bone marrow.

  1. Age is an important factor in bone marrow donation. People 60 years old or older cannot donate bone marrow. They have a higher risk of medical conditions..

  2. Certain medical conditions may disqualify individuals from becoming bone marrow donors. It includes HIV/AIDS, autoimmune diseases, bleeding disorders, recent cancer diagnoses, and severe chronic conditions.

Prerequisite Tests Required

Before becoming a bone marrow donor, individuals are required to undergo a series of prerequisite tests. These tests help determine eligibility and ensure the compatibility and safety of the donation process.

  1. Tissue Typing: A test to determine the compatibility of the donor's tissue with the recipient's.

  1. Blood Tests: These help assess overall health, check blood type, and screen for infectious diseases.

  1. Medical History Evaluation: Donors must provide detailed medical information to ensure eligibility.

  1. Physical Examination: A general physical examination evaluates the donor's overall health.

  1. Psychological Evaluation: Donors may undergo a psychological assessment to ensure their readiness for the donation process.

  1. Additional Screening: Depending on specific factors, additional tests or evaluations may be necessary, such as imaging studies or further laboratory tests.

Bone Marrow Matching

The bone marrow donor and the patient's human leukocyte antigens (HLAs) should be closely matched for a successful bone marrow transplant. If a potential donor's HLAs match well with a person who needs a transplant, they must provide a new blood sample to verify the match. 

Once the match is confirmed, a counsellor will explain the bone marrow donation process to the donor. They become a bone marrow donor, understand the procedure, and can provide informed consent.

Registration of Bone Marrow

Bone marrow registries connect potential bone marrow donors with people who need bone marrow transplants. The largest registry, Be the Match, maintains a database of registered donors and uses it to identify potential matches for patients. 

  1. To join a bone marrow donation registry, the bone marrow transplant donor age limit is 18 and 60, healthy and non-pregnant.

  2. People can register online or at any local donor registry drive. In-person drives only accept donors younger than 45 as their stem cells are more likely to help patients.

  3. Registration involves taking a sample of cells from the inside of the cheeks using a cotton swab or providing a small blood sample.

  4. The sample is then tested for special proteins called human leukocyte antigens (HLAs), which help the immune system distinguish between body tissue and foreign substances.

Donor Stay in The Hospital

Every individual's experience may vary. Specific details of the donor's stay in the hospital will depend on the medical centre.

Pre-Donation Evaluation

  1. Before the donation procedure, the donor will undergo a comprehensive medical evaluation.

  2. This evaluation includes a physical examination, blood tests, and imaging scans to ensure the donor's health and eligibility for donation.

Donation Procedure

  1. The donation procedure for bone marrow donors can vary depending on the specific type of donation.

  2. For peripheral blood stem cell (PBSC) donation, the donor may receive injections to increase the number of stem cells in their bloodstream. 

  3. The donation is made through apheresis, which involves blood extraction through a needle in one arm. 

  4. The blood is then passed through a machine to collect the stem cells before returning the remaining blood components to the donor through the other arm.

  5. The donor undergoes a surgical procedure under anaesthesia.  It is done by extracting of the bone marrow from the back of the pelvic bone using a needle.

Hospital Stay

  1. The length of the donor's hospital stay depends on the type of donation and individual circumstances.

  2. For bone marrow donation, a short hospital stay of one to two days may be required for monitoring and recovery.

What Happens During a Bone Marrow Donation?

During a bone marrow donation, stem cells can be collected in two ways. The most common method is through peripheral blood stem cell collection involving leukapheresis. 

  1. Before peripheral blood stem cell collection, the donor is given five days of shots to help stem cells move from the bone marrow into the blood.

  2. During peripheral blood stem cell collection, blood is removed from the donor through an IV in a vein. The white blood cells, including stem cells, are separated in a machine and extracted to be later donated to the bone marrow recipient.

  3. The RBCs are returned to the donor via an IV in the other arm.

  4. The procedure takes about 3 hours and can cause side effects such as headaches, sore bones, and discomfort from arm needles.

  5. Bone marrow harvest is a minor surgery that is done under general anaesthesia. The bone marrow is extracted from the backside of the pelvic bones and takes about 60 minutes.

  6. After a bone marrow harvest, the donor remains in the hospital until they're fully conscious and can eat and drink. Side effects include nausea, headache, fatigue, and bruising or discomfort in the lower back.

  7. Donors can resume regular activities within a week.

  8. There are some risks for the donor and no lasting health effects.

  9. The donor's body will replace the donated bone marrow in about 4 to 6 weeks.

Post-Procedure Donor Recovery

After the donation procedure, donors are provided with post-procedure instructions. Rest, hydration, and medications are given to support their recovery and well-being.

Recovery and Follow-up

  1. After the donation, the donor will be closely monitored for potential side effects or complications.

  2. The medical team will provide instructions for post-donation care, including rest, hydration, and any necessary medications.

  3. Donors typically have follow-up appointments to ensure their well-being and address any concerns or questions.

Complications After Bone Marrow Transplant

Bone marrow transplant is a complex medical procedure that can lead to various complications. While the procedure offers hope for treating certain conditions, it's important to be aware of the potential complications that may arise.

  1. Graft-versus-Host Disease (GVHD): The donor cells may attack the recipient's tissues. It can cause skin rashes, gastrointestinal problems, and liver or lung complications.

  2. Infection: Patients are more susceptible to infections due to the weakened immune system after the transplant. It ranges from common bacterial or viral infections to potentially life-threatening complications.

  3. Graft Failure or Rejection: The recipient's body may reject the transplanted cells. It can lead to a failed graft and need further treatments or a second transplant.

  4. Organ Damage or Toxicity: High-dose chemotherapy or radiation used in preparation for the transplant can damage organs. These include the liver, lungs, kidneys, or heart, potentially leading to long-term complications.

  5. Respiratory Issues: Post-transplant, patients may experience lung inflammation, infections, or complications like pneumonia. It necessitates close monitoring and appropriate medical intervention.

  6. Gastrointestinal Problems: Digestive system complications, including diarrhea, nausea, vomiting, or gut infections, can arise after the transplant..

Prevention of The Complications

Effective prevention strategies are crucial in mitigating complications in bone marrow donation, ensuring a safer and more successful transplant process.

  1. Graft-versus-Host Disease (GVHD): Administering medications to closely suppress the immune response and match donor and recipient tissue types.

  2. Infection: Strict adherence to infection control protocols, administering prophylactic antibiotics, and monitoring for signs of infection.

  3. Graft Failure or Rejection: Ensuring proper HLA matching between donor and recipient, following pre-transplant conditioning protocols, and closely monitoring engraftment.

  4. Organ Damage or Toxicity: Careful monitoring of organ function, adjusting medication doses, and managing potential side effects.

  5. Respiratory Issues: Regular monitoring of lung function, preventive measures to reduce the risk of respiratory infections, and prompt management of any respiratory symptoms.

  6. Gastrointestinal Problems: Proper nutrition support, monitoring for gastrointestinal complications, and early intervention in case of issues such as diarrhoea or mucositis.


Bone marrow transplantation is a lifesaving treatment for many patients with various blood-related diseases. However, many patients do not have a compatible donor within their family, highlighting the importance of bone marrow registries. Being willing to donate your bone marrow can significantly impact the life of someone in need.

While some risks and side effects are associated with the donation process, they are usually temporary and have no lasting health effects. We at HexaHealth strive to provide you with top-notch, effective consultation for your treatment. Reach out to our experts today and get started on the path to healthy living!

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Frequently Asked Questions

What is a bone marrow transplant donor?

A bone marrow transplant donor is an individual who provides healthy bone marrow or blood stem cells to a recipient who needs a transplant.

The donated cells replace damaged or diseased bone marrow in the recipient's body and help restore normal blood cell production.

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Who can be a bone marrow transplant donor?

The following criteria must be considered if you plan to become a bone marrow donor:

  1. Individuals who are in good overall health

  2. Age requirements vary but generally range from 18 to 60 years old

  3. Willingness to undergo medical and compatibility tests

  4. Matching HLA tissue type with the recipient

  5. Meeting eligibility criteria set by the transplant centre

  6. Non-smokers or individuals who have quit smoking for a certain period

  7. Absence of certain medical conditions or infections

  8. Willingness to commit to the donation process and follow-up appointments

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What is the process for becoming a bone marrow transplant donor?

Below is the process of becoming a bone marrow transplant donor:

  1. Find a bone marrow registry or organisation that facilitates donor registration.

  2. Fill out the registration form, providing personal information and medical history.

  3. Consent to the necessary tests, including blood or cheek swab samples for HLA typing.

  4. Your information will be added to the registry, which will be accessible for potential matches.

  5. You will be contacted for further testing and evaluation if identified as a potential match.

  6. You will undergo a thorough medical assessment to ensure your eligibility if deemed a suitable match.

  7. Once cleared, you will be informed about the donation process, including the type of donation required (e.g., peripheral blood stem cells or bone marrow).

  8. If selected as the donor, you will proceed with the donation procedure, which medical professionals will coordinate and guide.

  9. After the donation, you will receive post-donation care and support, including follow-up appointments to monitor your recovery.

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What are the different types of bone marrow transplant donors?

There are different types of bone marrow transplant donors:

  1. Related Donor: A family member, such as a sibling or parent, who is a close biological match to the recipient.

  2. Unrelated Donor: An individual unrelated to the recipient but with a compatible tissue type. They can be found through national and international registries.

It is important to note that the type of donor selected depends on the recipient's specific needs and the availability of suitable matches.

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How to donate bone marrow?

To donate bone marrow, the process typically involves:

  1. Registration: Sign up with a bone marrow registry and provide your information.

  2. Tissue Typing: Undergo a blood test or cheek swab to determine your tissue type.

  3. Match Identification: Further testing and evaluation will be conducted if you're a potential match.

  4. Medical Evaluation: Complete a comprehensive medical evaluation to ensure you're healthy for donation.

  5. Donation Procedure: Choose between Peripheral Blood Stem Cell (PBSC) donation or Bone Marrow donation.

  6. Recovery: You'll be monitored for any side effects or complications after donation.

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Are there any bone marrow transplant donor risks?

When considering becoming a bone marrow transplant donor, it's important to be aware of the potential risks involved, which may include:

  1. General Anesthesia: If you opt for a bone marrow donation procedure, you may undergo anaesthesia, which carries its risks.

  2. Infection: There is a small risk of infection associated with the donation process.

  3. Discomfort and Side Effects: Some donors may experience temporary side effects such as fatigue, headache, or body aches.

  4. Allergic Reactions: There is a slight possibility of experiencing allergic reactions to medications given during donation.

  5. Bleeding and Bruising: There is a minimal risk of bleeding and bruising at the site where blood is drawn or during the donation procedure.

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Who cannot donate bone marrow?

While many individuals can become bone marrow donors, certain factors may disqualify someone from donating. Some common reasons why individuals may not be able to donate bone marrow include:

  1. Age Restrictions: Donors must typically be within a specific age range, often between 18 and 60 years old.

  2. Medical Conditions: Certain medical conditions may disqualify individuals from donating, such as cancer or autoimmune diseases.

  3. Lifestyle Factors: Certain lifestyle choices, such as intravenous drug use, may make an individual ineligible to donate due to the potential risk of transmitting infections.

  4. Pregnancy: Pregnant individuals are generally not eligible to donate bone marrow until a certain period after giving birth.

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What is the difference between an autologous and allogeneic bone marrow transplant donor?

The main difference between an autologous and allogeneic bone marrow transplant donor is as follows:

Autologous Bone Marrow Transplant Donor:

  1. The donor is the individual themselves.

  2. Stem cells are collected from the patient's own bone marrow or peripheral blood before undergoing high-dose chemotherapy or radiation.

  3. The collected stem cells are frozen and stored for later use.

  4. The purpose of the transplant is to replace or restore the patient's damaged or destroyed bone marrow.

Allogeneic Bone Marrow Transplant Donor:

  1. The donor is another person, either related or unrelated to the patient.

  2. The donor is typically a close match to the patient's tissue type, determined by human leukocyte antigen (HLA) matching.

  3. Stem cells are collected from the donor's bone marrow or peripheral blood or, in some cases, obtained from umbilical cord blood.

  4. The donated stem cells are then transplanted into the patient.

  5. The purpose of the transplant is to replace the patient's diseased or malfunctioning bone marrow with healthy donor cells, which can help treat various medical conditions.

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How do you find a bone marrow match?

Finding a bone marrow match is typically done through human leukocyte antigen (HLA) matching. HLA markers are proteins that play a crucial role in determining tissue compatibility. 

The most closely matched donors are usually sought to minimise the risk of rejection. Initially, potential matches are sought within the patient's family, particularly siblings.

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Is there any age criteria to become a bone marrow donor?

The age criteria for becoming a bone marrow donor may vary. Generally, individuals between the ages of 18 and 60 are eligible to register as potential donors.

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How does bone marrow donation affect the donor's health?

Bone marrow donation has a minimal long-term impact on the donor's health. After peripheral blood stem cell (PBSC) donation, the donor's bone marrow replenishes within weeks.

Temporary side effects like fatigue, bone pain, or bruising are common but resolve on their own as the body adjusts.

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Are there any risks associated with bone marrow donation?

While bone marrow donation is generally safe, there are some risks involved:

  1. The risks associated with bone marrow donation include infection, bleeding, allergic reactions to anaesthesia, and damage to nearby tissues or organs.

  2. Donors may experience temporary side effects such as fatigue, pain at the donation site, bruising, or discomfort during recovery.

  3. Serious complications are rare, and the medical team takes every precaution to minimise risks and ensure donor safety.

  4. Prior to donation, potential donors undergo thorough medical evaluations to assess their suitability.

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What is the recovery process for a bone marrow donor?

Here is what the recovery process for a bone marrow donor looks like:

  1. The recovery process for a bone marrow donor varies from person to person, but it typically involves a period of rest and monitoring.

  2. Donors may experience fatigue, soreness, or discomfort at the donation site, which usually resolves within a few days or weeks.

  3. The donor's bone marrow replenishes within a few weeks, and the body adjusts to the donated cells.

  4. Donors need to follow the post-donation guidelines provided by the medical team, which may include taking medications, maintaining a healthy diet, and avoiding strenuous activities.

  5. Regular follow-up appointments and check-ups are scheduled to ensure the donor's well-being and monitor their recovery.

  6. Donors are encouraged to communicate any concerns or unexpected symptoms to their healthcare team during recovery.

  7. The medical professionals involved in the donation process provide support and guidance throughout recovery.

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How does bone marrow donation affect the donor's immune system?

Bone marrow donation has minimal long-term effects on the donor's immune system. The body replenishes the donated bone marrow or stem cells.

The immune system returns to normalcy within a few weeks to a few months after the donation.

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How does bone marrow donation affect the donor's ability to have children?

Bone marrow donation does not typically affect the donor's ability to have children. The donation process involves collecting bone marrow, which does not impact reproductive organs. Donors can usually conceive and have children after donation without any adverse effects.

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Can a bone marrow donor donate again in the future?

Yes, individuals who have previously donated bone marrow or stem cells can donate again in the future.

If their tissue type matches a recipient in need, they may be contacted for subsequent donations.

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How can one support a loved one considering being a bone marrow donor?

Supporting a loved one considering being a bone marrow donor involves providing information, encouragement, and emotional support throughout the process. Here are some ways to support them:

  1. Educate yourself: Learn about the bone marrow donation process, the potential impact on the donor, and the benefits it can bring to the recipient.

  2. Offer emotional support: Be understanding and empathetic towards their decision. Listen to their concerns and provide reassurance during any anxieties they may have.

  3. Provide information: Help them gather information about the donation process, including the medical procedures, recovery period, and potential risks and benefits.

  4. Accompany them to appointments: Offer to accompany your loved one to medical appointments, providing moral support and assistance with any necessary arrangements.

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How does bone marrow donation differ from blood donation?

Bone marrow donation involves a surgical procedure, while blood donation is non-surgical. Bone marrow is a one-time commitment, while blood donation can be more frequent.

Donated components differ, with bone marrow providing stem cells and blood donation offering various blood components.

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Are there any financial considerations for bone marrow donors?

  1. In most cases, the bone marrow donor has no direct financial costs. The recipient's insurance or transplant centre usually covers the expenses related to the donor's evaluation, surgery, and follow-up care.

  2. However, there may be indirect costs, such as transportation and lodging, if the donation requires travel. Some programs provide financial assistance or reimbursement for these expenses.

  3. Employers may offer paid leave or time off for donation-related procedures. The donor should check their company's policies regarding leave for bone marrow donation.

  4. Donors need to communicate with the transplant centre to understand any financial considerations and support available to them.

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How does the process of bone marrow donation affect the donor's work or school schedule?

The process of bone marrow donation may temporarily impact the donor's work or school schedule.

Donors may need to take time off for medical evaluations, the donation procedure, and the recovery period.

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How is the privacy of bone marrow donors protected?

The privacy of bone marrow donors is protected through various measures. Personal and medical information is handled confidentially in accordance with privacy laws and regulations. 

Donor information is typically stored securely and shared only with authorised individuals. Donors' identities are protected unless they choose to disclose their donation status.

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What are the legal requirements for bone marrow donation?

The legal requirements for bone marrow donation may vary, but some common considerations include:

  1. Age: Donors must typically be over a certain age, such as 18 or 21, to ensure legal consent.

  2. Health: Donors should be in good overall health and free from certain medical conditions that could pose risks to the donor or recipient.

  3. Consent: Donors must provide informed consent and may need to complete legal documentation.

  4. Genetic Testing: Donors may undergo genetic testing to determine compatibility with the recipient.

  5. Confidentiality: Donor information is typically kept confidential and protected by privacy laws.

  6. Voluntary Donation: Donation should be voluntary, without any financial or other undue inducements.

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How can one become an advocate for bone marrow donation?

Becoming an advocate for bone marrow donation involves raising awareness and promoting the importance of donation. Here are some ways to get involved:

  1. Educate Yourself: Learn about the benefits and impact of bone marrow donation, including success stories and patient experiences.

  2. Share Information: Use social media, personal networks, and community platforms to spread information about bone marrow donation, its significance, and how to get involved.

  3. Organise Events: Plan and host events like awareness campaigns, information sessions, or donor registration drives in collaboration with relevant organisations.

  4. Volunteer: Offer your time and skills to assist organisations involved in bone marrow donation, such as helping with awareness campaigns, fundraising, or coordinating events.

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What are some myths and facts about bone marrow donation?

  1. Myth: After donating, bone marrow involves opening up or removing bones.
    Fact: This common myth scares many people away from donating bone marrow. However, most blood stem cell donors give peripheral blood stem cells. This process is similar to donating plasma and does not involve opening up or removing bones.

  1. Myth: Bone marrow donation is very painful 
    Fact: Many people believe donating bone marrow is painful and invasive. However, donating is less painful than most people think. A series of injections assist the transport of stem cells from the bone marrow into the bloodstream during peripheral blood stem cell donation. There is a chance of discomfort during the procedure, but it is not often unpleasant.

  1. Myth: Donating takes a long time.
    Fact: The process of donating bone marrow does not take a long time. Peripheral blood stem cell donation usually takes about three hours. The bone marrow harvest process takes about an hour. The time commitment is minimal when considering that donating can save someone’s life.

  1. Myth: Donation is expensive, and you need medical insurance.
    Fact: Donating bone marrow is accessible to the donor. The recipient’s insurance covers all medical expenses related to the donation process. Donors do not need to have medical insurance to donate.

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All the articles on HexaHealth are supported by verified medically-recognized sources such as; peer-reviewed academic research papers, research institutions, and medical journals. Our medical reviewers also check references of the articles to prioritize accuracy and relevance. Refer to our detailed editorial policy for more information.

  1. Bone Marrow Donation: Who Can Donate and How It Works [Internet]. Cleveland Clinic. [cited 2023 Jul 6]. link
  2. Myths And Facts About Bone Marrow Donation | Be The Match [Internet].
  3. Mayo Clinic. Blood and bone marrow stem cell donation - Mayo Clinic [Internet]. 2018. link
  4. Bone marrow (stem cell) donation: MedlinePlus Medical Encyclopedia [Internet]. 2020. link
  5. Becoming a Bone Marrow Donor [Internet]. [cited 2023 Jul 6].link
  6. What is a Bone Marrow Transplant (Stem Cell Transplant)? [Internet].
  7. Johns Hopkins Medicine. Bone Marrow Transplantation [Internet]. Johns Hopkins Medicine. 2019. link

Updated on : 17 July 2023


Dr. Aman Priya Khanna

Dr. Aman Priya Khanna

MBBS, DNB General Surgery, Fellowship in Minimal Access Surgery, FIAGES

12 Years Experience

Dr Aman Priya Khanna is a well-known General Surgeon, Proctologist and Bariatric Surgeon currently associated with HealthFort Clinic, Health First Multispecialty Clinic in Delhi. He has 12 years of experience in General Surgery and worke...View More


Sangeeta Sharma

Sangeeta Sharma

BSc. Biochemistry I MSc. Biochemistry (Oxford College Bangalore)

6 Years Experience

She has extensive experience in content and regulatory writing with reputed organisations like Sun Pharmaceuticals and Innodata. Skilled in SEO and passionate about creating informative and engaging medical conten...View More

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