Dr. Rajib De

Dr Rajib De is a Lead Consultant and Clinical Lead in Clinical Haematology, Haemato-Oncology, and Bone Marrow Transplant in Kolkata with 29 years of experience in the management of blood cancers, benign blood disorders, and stem cell transplantation.

He holds a DM in Clinical Haematology from Medical College, Kolkata, a Fellowship in BMT from Tata Memorial Hospital, Mumbai, and has completed Training in CAR-T Cell Therapy at Tata Memorial Hospital, Mumbai (2025). He is a Professor of Haematology at NRS Medical College, Kolkata and currently serves as Lead Consultant at Manipal Hospital, EM Bypass.

Patients seeking expert bone marrow transplant in Kolkata, trusted leukaemia and lymphoma treatment in EM Bypass, or advanced CAR-T cell therapy in West Bengal will find Prof Dr De at Manipal Hospital EM Bypass, SONOSCAN Diagnostic Beniapukur, and Balaji Healthcare Sevoke Road.

He was the first to perform autologous stem cell transplantation at Medical College Calcutta in 2009 and the first to perform allogeneic stem cell transplant for acute leukaemia under the Government of West Bengal in 2012 and has performed over 200 bone marrow transplants across his career.

He is a Fellow of the Indian College of Haematology (FICH) and Nodal Officer of the Multidisciplinary Research Unit at NRS Medical College under the Department of Health Research, Government of India.

He consults in English, Hindi, and Bengali, ensuring clear communication for patients from across eastern India.

Specialty Areas and Treatments

Prof Dr Rajib De manages the complete spectrum of benign and malignant haematological conditions through evidence-based clinical protocols with dedicated subspecialty focus on bone marrow transplantation, CAR-T cell therapy, and haemato-oncology.

Bone Marrow Transplant in Kolkata

Prof Dr De is one of eastern India's most experienced bone marrow transplant physicians with over 200 BMTs performed across his career:

• Autologous Stem Cell Transplant for multiple myeloma, lymphoma, and selected solid tumours
• Allogeneic Stem Cell Transplant for leukaemia, MDS, aplastic anaemia, and thalassaemia
• Haploidentical Stem Cell Transplant for patients without matched sibling or unrelated donors
• Matched Unrelated Donor (MUD) Transplant with experience from Tata Memorial Hospital training
• Pre-Transplant Evaluation including HLA typing, organ function assessment, and fitness workup
• Post-Transplant Care including GVHD management, infection surveillance, and engraftment monitoring
• BMT for Thalassaemia as curative treatment option for eligible patients

CAR-T Cell Therapy in West Bengal

Prof Dr De completed dedicated Training in CAR-T Cell Therapy at Tata Memorial Hospital, Mumbai in 2025, making him one of the few haematologists in eastern India with formal CAR-T training:

• CAR-T Cell Therapy for relapsed and refractory B-cell lymphoma
• CAR-T Cell Therapy for relapsed and refractory ALL
• Patient Selection and Eligibility Assessment for CAR-T cell therapy
• Post-CAR-T Monitoring including CRS and neurotoxicity management

Blood Cancer Treatment in EM Bypass

Prof Dr De manages all categories of haematological malignancies:

• Acute Myeloid Leukaemia (AML) intensive induction and consolidation chemotherapy
• Acute Lymphoblastic Leukaemia (ALL) paediatric and adult protocols with published research
• Acute Promyelocytic Leukaemia (APL) ATRA and arsenic-based regimens
• Chronic Myeloid Leukaemia (CML) TKI therapy and monitoring
• Chronic Lymphocytic Leukaemia (CLL) targeted therapy and immunotherapy
• Hodgkin Lymphoma ABVD and escalated regimens
• Non-Hodgkin Lymphoma R-CHOP and novel agents across all subtypes
• Multiple Myeloma proteasome inhibitors, immunomodulatory agents, and daratumumab
• Myelodysplastic Syndromes (MDS) hypomethylating agents and supportive care
• Myeloproliferative Neoplasms polycythaemia vera, essential thrombocythaemia, and myelofibrosis with published research

Aplastic Anaemia and Bone Marrow Failure in Howrah

• Aplastic Anaemia immunosuppressive therapy and stem cell transplantation with published outcomes data
• Inherited Bone Marrow Failure Syndromes including Fanconi anaemia
• Myelofibrosis JAK inhibitor therapy and transplantation evaluation
• Bone Marrow Aspiration and Trephine Biopsy for diagnosis and staging

Thalassaemia and Haemoglobinopathies in Beniapukur

Prof Dr De has dedicated research funding from DST and ICMR for thalassaemia with ongoing studies on RBC phosphatidylserine and HbF inducers:

• Thalassaemia Major and Intermedia transfusion protocols and iron chelation therapy
• Haemoglobin E Beta Thalassaemia with published research on glucose homeostasis and pulmonary hypertension
• Sickle Cell Disease hydroxyurea therapy and crisis management
• Haemoglobinopathy Genetic Counselling including alpha and beta thalassaemia mutation screening
• Iron Chelation Therapy for transfusion-dependent patients
• Phenotype-Matched RBC Transfusion for thalassaemia patients with published research

Bleeding and Clotting Disorders in Kolkata

• Haemophilia A and B factor replacement therapy and surgical haemostasis
• Von Willebrand Disease diagnosis and treatment
• Immune Thrombocytopenia (ITP) steroids, IVIg, and second-line agents
• Thrombocytopenia evaluation and management
• Disseminated Intravascular Coagulation (DIC) acute management
• Thrombophilia Workup for recurrent clots and pregnancy loss
• Deep Vein Thrombosis and Pulmonary Embolism anticoagulation management
• Thrombotic Disorders including antiphospholipid syndrome

Anaemia Management in West Bengal

• Iron Deficiency Anaemia evaluation and intravenous iron therapy
• Vitamin B12 and Folate Deficiency Anaemia
• Haemolytic Anaemia autoimmune and microangiopathic types
• Anaemia of Chronic Disease
• Refractory Anaemia in MDS context

Laboratory Haematology and Diagnostics

• Bone Marrow Aspiration and Biopsy
• Flow Cytometry and Immunophenotyping for leukaemia and lymphoma
• HPLC for Haemoglobin Variants thalassaemia and sickle cell diagnosis
• Cytogenetic and Molecular Testing BCR-ABL, JAK2, FLT3, NPM1
• PET-CT Based Bone Marrow Involvement Assessment in lymphoma with published research
• Coagulation Profile Interpretation

Qualifications

• MBBS from Medical College, Kolkata (1997)
• MD Internal Medicine from Institute of Post Graduate Medical Education and Research (IPGMER), Kolkata (2004)
• DM Clinical Haematology from Institute of Haematology and Transfusion Medicine (IHTM), Medical College, Kolkata (2010)
• Fellowship in BMT, Tata Memorial Hospital, Mumbai (2012)
• Training in CAR-T Cell Therapy, Tata Memorial Hospital, Mumbai (2025)
• FICH, Fellow of the Indian College of Haematology
• Training in Bone Marrow Transplantation, AIIMS, New Delhi (February 2010 to April 2010)

Prof Dr De holds active medical council registration with the Bengal Medical Council (Reg. No. 53827, 1997).

Milestones and Clinical Achievements

• First to perform Autologous Stem Cell Transplantation at Medical College Calcutta in August 2009
• First to perform Allogeneic Stem Cell Transplant for Acute Leukaemia under the Government of West Bengal at NRS Medical College in October 2012
• Over 200 bone marrow transplants performed including Autologous, Allogeneic, and Haploidentical transplants for myeloma, lymphoma, leukaemia, thalassaemia, and aplastic anaemia
• Established BMT unit at Narayana Superspeciality Hospital, Howrah from scratch and performed 84 BMTs there
• Professor of Haematology, NRS Medical College, Kolkata training DM Clinical Haematology students
• Nodal Officer, Multidisciplinary Research Unit (MRU), NRS Medical College under Department of Health Research, Government of India
• Involved in multiple multicentric and multinational clinical trials as Principal and Co-Investigator
• Patent holder for Ferritin Biosensor technology (US Patent 20120052014 A1, March 2012) with co-inventors
• Author of chapters in multiple haematological textbooks including Haematology Today, Management of Acute Leukemia, Myeloproliferative Neoplasms, and National Guideline on Thalassaemia

Research and Publications

Prof Dr De has an extensive publication record in indexed national and international haematology journals. Selected recent publications:

• Gut Microbiome as a Predictive Biomarker for Febrile Neutropenia in Pediatric Acute Lymphoblastic Leukaemia: A Clinical Integrative Framework, Indian Journal of Medical and Paediatric Oncology, 2026
• Detection of Common Deletion Mutations in HBA Gene and Genotype-Phenotype Correlation, Archives of Clinical and Biomedical Research, 2025, 9(2): 122 to 126
• Role of Phenotype-Matched RBC in Reducing Transfusion Requirement in Thalassemia Patients, Blood, November 2024, 144(Supplement 1): 5611
• Differential Erythrocyte Phosphatidylserine Exposure Associated with Variations in Clinical and Haemostatic Parameters in E Beta and Beta Thalassemia, Blood, 2022, 140(Supplement 1): 5367 to 5368
• Utility of 18F-FDG PET-CT Scan in Detecting Bone Marrow Involvement in Lymphoma, Indian Journal of Medical Research, 2021, 154(5): 691 to 698Response to Immunosuppressive Therapy in Acquired Aplastic Anaemia: Experience of a Tertiary Care Centre from Eastern India, Indian Journal of Hematology and Blood Transfusion, 2021, 37(2): 197 to 203
• A Glimpse into Translocation (8;21) in Acute Myeloid Leukaemia: Profile and Therapeutic Outcomes from a Tertiary Care Haematology Centre from East India, Journal of Hematology and Allied Sciences, 2022, 2: 85 to 90

Professional Memberships

• Fellow, Indian College of Haematology (FICH)
• Nodal Officer, EIBMCT (Eastern India Blood Marrow and Cellular Therapy), EHG
• Executive Committee Member, Indian Society of Haematology and Blood Transfusion (ISHBT)
• Assistant Secretary, Bengal Society of Haematology
• Member, Indian Stem Cell Transplant Registry Group
• Member, Indian Stem Cell Transplant Group

About Manipal Hospitals, Kolkata

Manipal Hospitals is one of India's largest and most trusted tertiary care hospital networks with a presence across 18 cities in India.

Manipal Hospital EM Bypass, Kolkata is one of eastern India's most advanced multispeciality hospitals offering dedicated Clinical Haematology, Haemato-Oncology, Bone Marrow Transplant, Cancer Care, Robotic Surgery, Cardiac Sciences, and Organ Transplant centres of excellence.

The hospital is NABL accredited and follows a multidisciplinary tumour board approach ensuring personalised and evidence-based care for every patient.

Hospital Affiliations in Kolkata

Current Practice

• Manipal Hospital, EM Bypass, Kolkata as Lead Consultant and Clinical Lead, Clinical Haematology, Haemato-Oncology and BMT, ₹1250
• SONOSCAN Diagnostic, Beniapukur, Kolkata as Consultant, ₹1350
• Balaji Healthcare, Sevoke Road as Consultant, ₹1350

Past Experience

• Nil Ratan Sarkar Medical College and Hospital, Raja Bazar, Kolkata as Professor, Department of Haematology
• NH Rabindranath Tagore International Institute of Cardiac Sciences, Mukundapur as Clinical Lead, BMT Programme
• Narayana Superspeciality Hospital, Shibpur, Howrah as Consultant and Clinical Lead, BMT Programme (established BMT unit, performed 84 BMTs)

Book an Appointment with Prof Dr Rajib De, Haematologist in Kolkata

To check consultation fees and book a priority appointment with Prof Dr Rajib De at Manipal Hospital EM Bypass or SONOSCAN Diagnostic Beniapukur, visit HexaHealth for a smooth and hassle-free booking experience.