When to Worry about Creatinine Levels Low or High?

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Written by Hexahealth Care Team, last updated on 14 December 2023
When to Worry about Creatinine Levels Low or High?

Creatinine is one of the human body's nitrogenous end products of metabolism. So how does it build up, and when to worry about creatinine levels? Generally, it builds up with muscle breakdown and eventually flushes out of the body with urine. What makes creatinine particularly important is that nephrologists use it as an important marker to diagnose kidney disease. 

If the levels get on the higher side or even become too low, this is the time when you should worry about creatinine levels, as the parameters indicate potential damage to health. As creatinine is used to determine kidney health, any changes in serum creatinine levels in the blood indicate a kidney function problem. This is when to worry about low creatinine levels. Continue to read and learn about the causes, symptoms and treatment for low creatinine levels.

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Creatinine and Its Level

Creatinine is a type of serum produced by the metabolism of muscles in the body. As creatine offers energy to the muscle, its by-product, creatinine, is absorbed in the blood. While the body continuously produces creatinine, kidneys extract this substance from the blood and excrete it out of the body. 

Creatinine is a key metric used to evaluate kidney function and general health. Understanding its importance can aid in the diagnosis and treatment of a variety of health disorders because it plays a key role in the body. Here are some crucial details emphasising the importance of creatinine:

  1. Kidney function
  2. Diagnostic tool for kidney diseases
  3. Evaluation of medication dosage
  4. Muscle mass indicator

The normal range of serum creatinine in the blood is 0.6 to 1.2 mg/dL (for males) and 0.5 to 1.1 mg/dL (for females) when the kidneys function properly. Any deviation from the accepted range indicates a serious underlying health condition. 

Furthermore, doctors use a creatinine clearance test to determine how efficiently your kidneys can remove creatinine from the bloodstream. The person may require medical guidance if the levels are higher or lower than normal.

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Symptoms of Low Creatinine Levels

It is difficult to recognise impaired kidneys because a reduced kidney function shows no discernible symptoms. Most physical symptoms manifest only later when the kidneys are already damaged.

If creatinine levels fall below the normal range, it may suggest a health-related anomaly in the body. Some symptoms commonly identified with low creatinine levels are

  1. Fatigue or Weakness
  2. Muscle Cramps
  3. Breathing difficulties
  4. Changes in urination
  5. Nausea
  6. Brain fog
  7. Lack of appetite

Causes of Low Creatinine Levels

Nevertheless, any drastic change in serum creatinine levels is not only caused by kidney damage. Other temporary and chronic underlying conditions can alter the serum creatinine levels in the blood. Find below some of the causes that may lead to low creatinine levels: 

  1. Low Muscle Mass: Creatinine levels in the body are mostly linked with muscle mass or the amount of muscle in the body. With increasing age, the muscle mass decreases, which eventually leads to low creatinine levels.
  2. Liver Disease: The liver produces creatine, which is then absorbed by muscles and forms creatinine. When the liver does not function properly, it fails to produce sufficient amounts of creatine. 
  3. Malnutrition: Creatinine is a by-product of creatine phosphate in muscle, and its production is proportional to muscle mass. If there is not enough creatinine in the blood, it may result from a severe lack of muscles in the body. It may also indicate a lack of protein in the diet. 
  4. Pregnancy: Pregnancy is often a contributing factor that reduces creatinine levels in the blood. It is a temporary condition, and the serum creatinine levels restore to normal after giving birth. 

Risks Factors of Low Creatinine Levels 

While low creatinine can be a temporary condition resulting from numerous external reasons, it may also indicate some severe health anomalies. On the contrary, a higher amount of creatinine in the blood almost invariably indicates impaired kidney function.

The following are some of the risk factors that might contribute to low creatinine levels in the body:

  1. Older age
  2. Obesity
  3. Diabetes mellitus
  4. Kidney dysfunction
  5. Family history of kidney disease
  6. Medications that affect kidney functions
  7. High blood pressure
  8. Cardiovascular disease 

Diagnosing Low Creatinine Levels

A thorough assessment by a healthcare professional is required to diagnose low creatinine levels in order to discover the underlying cause and the best course of treatment. Here are some typical diagnostic procedures and examinations that may be carried out:

  1. Medical Assessment: The healthcare provider will begin by getting a complete medical history, which will include any known illnesses, drugs, and symptoms. They could enquire about conditions, including muscle atrophy, liver illness, or kidney malfunction that could cause low creatinine values.
  2. Blood and Urine Tests:  A vital tool for identifying low creatinine levels is a blood and urine test. Creatinine levels in the blood can be determined using a comprehensive metabolic panel or renal function panel. Low levels of creatinine can be used to evaluate renal function and pinpoint likely reasons, along with other pertinent blood indicators.

Treatment for Low Creatinine Levels

Treatment for low creatinine levels focuses on addressing the underlying cause and restoring normal creatinine levels. The specific treatment approach will depend on the underlying condition contributing to low creatinine. Here are some common treatment strategies:

  1. Treating Underlying Medical Conditions: The main focus will be on managing and treating the underlying medical condition if low creatinine levels are brought on by liver disease or kidney dysfunction. This could entail using drugs, altering one's lifestyle, or undergoing other prescribed measures.
  2. Medication Adjustment: Medication side effects might occasionally cause low creatinine levels. To return creatinine levels to normal, medical practitioners may examine and modify the amount or kind of medicine. Before changing a patient's prescription regimen, it's crucial to speak with a healthcare professional.
  3. Improving Muscle Mass: If muscle wasting or loss is the cause of low creatinine levels, improving muscle mass may be advised. This can involve regular exercise, resistance training, and physical treatment to encourage muscle strength and growth. A medical practitioner or trained fitness specialist can offer advice on proper workouts and intensity levels.

It's crucial to regularly check your creatinine levels so you can judge how well your treatment is working and make any required adjustments. For the purpose of monitoring creatinine levels and assessing renal function, this may entail routine blood tests.

Follow-up consultations with a medical expert will enable the continuing assessment and management of reduced creatinine levels.

Preventive Measures to Improve Creatinine Levels

Low creatinine levels in an individual can lead to kidney disorders and eventually lead to poor quality of life. Thus, it is important to understand and undertake preventive measures to improve creatinine levels. 

Lifestyle Changes 

Following a healthy diet plan, the next action must be following a healthy and moderately active lifestyle to boost muscle mass. 

A lack of creatinine indicates a severe lack of muscle mass. It impacts a person’s physical appearance, hampers their stamina, and comes in the way of a healthy life. Incorporating some of the following physical activities in your everyday life can improve creatinine levels while also improving the quality of life:

  1. Walking: Moderate to fast-paced walking is a great way to work your leg muscles. Weekly training increases the stamina of a person while also improving skeletal quality and overall body strength.
  2. Swimming: It is one of those activities that can target all the muscles in the body, making it a great option for full-body exercise.
  3. Weightlifting: Start with a small amount of weight and fewer repetitions and increase over time as your tolerance increases. Perform this only after two weeks of changing your diet and lifestyle. This is one of the most effective ways to increase body mass, thereby increasing creatinine quantity in the blood.  
  4. Bicycling: Few physical activities are effective as well as refreshing at the same time. Light to moderate bicycling regularly is a useful cardiovascular activity to build your stamina while also targeting the core, quads and hamstring muscles.

Hence, including a few of these changes in your life is a great way to increase serum creatinine levels in the bloodstream naturally. 

Dietary Changes 

When it comes to low creatinine levels, an inefficient diet plan almost invariably lies at the root of the cause. Nowadays, poor-quality diets and heavy dependency on fast foods are one of the factors that cause lower creatinine levels in the blood. 

Incorporating more nutritious whole foods in your diet effectively increases the creatinine quotient in your blood. Food items rich in macronutrients promote muscle development and increase serum creatinine in the blood. You may include some of the following foods in your diet:  

  1. Meat: Red meats are a rich source of protein in the human body. It helps efficiently build lean muscle mass while contributing to increased creatinine production.
  2. Eggs: Eggs are a great source of protein and good fats. Make it a part of your everyday diet to build stamina and fill your body with healthy nutrients.   
  3. Lentils: If you are a vegetarian, several foods rich in protein can produce positive results for your body. Various groups of lentils are a rich source of protein and micronutrients to balance your creatinine levels. 
  4. Legumes: Legumes and several classes of beans such as soybean, chickpeas and kidney beans are a great source of antioxidants. They flush out toxins from the body and promote better digestive health. These proteins are also easily digestible and the body absorbs them more efficiently.  
  5. Greek Yoghurt: Greek yoghurt is a rich source of protein, Vitamin B12 and selenium along with several gut-friendly bacteria that helps neutralise stomach acids. It also boosts metabolism, which promotes better digestion and protein absorption in the body.
  6. Creatine Supplement: You may also opt for over-the-counter creatine supplements to boost your creatinine levels. These supplements help to develop muscle mass in the body, so ensure you are engaging in moderate strength training for best results. 

Blood absorbs a very small amount of creatinine from food; most of the creatinine in the bloodstream is produced in the body.  So, building healthy muscle mass is essential to improve creatinine levels in the blood.

When to See a Doctor?

If your lab tests for serum creatinine indicate higher than normal range or, below the normal range, you should visit a nephrologist. A nephrologist is a specialist in kidney function who can accurately identify related health problems. They may prescribe further tests to provide an accurate diagnosis regarding your condition.

Here are some situations where you should seek medical attention:

  1. Persistent or Unexplained Low Creatinine Levels: If your creatinine levels remain low over several tests or your doctor can't explain why your creatinine levels are low, it's essential to see a doctor.
  2. Symptoms of Kidney Disease: Symptoms of kidney disease can include fatigue, nausea, vomiting, swollen ankles, and changes in urination.
  3. History of Kidney Disease: If you have had a history of kidney disease or kidney issues, you should consult a doctor to ensure your low creatinine levels aren't an indication of a condition worsening.
  4. Taking a Drug that Interferes with Kidney Function: Some drugs, including diuretics, can decrease creatinine levels. You should speak to your doctor if you take medication that affects kidney function and has low creatinine levels.
  5. History of Kidney Disease in your Family: If kidney disease runs in your family, you should visit a doctor to ensure that your low creatinine levels aren't a symptom of an inherited disease.

It is important to get a diagnosis as soon as possible to discern the cause behind the abnormal creatinine levels and get it treated properly.

Takeaway

Low levels of creatinine can be concerning since they could be a sign of a health problem or physical imbalance. Although occasional changes in creatinine levels may not be concerning, persistently low values should be assessed by a healthcare provider. Individuals can better determine when to seek medical assistance by being aware of the possible risks, causes, and symptoms connected with low creatinine levels.

If you have fluctuating creatinine levels and are considering when to worry about creatinine levels, check out expert healthcare guidance and solutions from HexaHealth. As India’s one of the most trusted HealthTech platforms, HexaHealth offers accurate diagnosis and effective solutions to ever-changing creatinine levels.

Suggested Reads,

Serum Creatinine Test Kidney Diagnostic Tests
Chronic Kidney Disease Abdominal Pain

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Frequently Asked Questions

When to worry about creatinine levels?

Your answer for When to worry about creatinine levels is If serum creatinine levels are either higher or lower than the normal range, one should immediately seek medical guidance.  You may check out expert solutions from HexaHealth.

When to worry about low creatinine levels?

People often wonder when to worry about low creatinine levels. It is a matter of concern when creatinine levels drop below 0.5 mg/dL in women and 0.7 mg/dL in men.

You will experience severe symptoms such as frequent exhaustion, fatigue, nausea, shortness of breath and muscle stiffness in severe cases. Since low creatinine levels indicate a lack of nutrition, the patient experiences severe energy depletion.

What is creatinine, and why is it important to measure?

Creatinine is a by-product of muscle metabolism found in the blood. Doctors use creatinine as a marker to identify kidney health, as excessive creatinine means kidneys are not functioning properly.

What is the normal range for creatinine levels in the blood?

The normal range for creatinine in adults is 0.6-1.2 mg/dL for males and 0.5-1.1 mg/dL for females. Variation in the nutrition, lifestyle and intensity of physical activity leads to variation in creatinine levels.

What are the causes of low creatinine levels?

Low creatinine in the blood can indicate various conditions: 

  1. lack of nutrition in the body
  2. poor muscle mass 
  3. liver disease

Can low creatinine levels be a sign of kidney disease?

Low creatinine volume in the blood may refer to multiple underlying health conditions such as kidney failure and liver disease. It also refers to protein deficiency in the body.

What are the symptoms of low creatinine levels?

Weakness in muscles, stiffness, pain and fatigue are common symptoms of low creatinine levels. This might be due to a condition called muscular dystrophy. Symptoms like jaundice, abdominal pain and swelling, and bloody, pale or tar-coloured stools may be seen when it interferes with liver functions.
In some cases, excess water loss may also be seen.

How are low creatinine levels diagnosed and treated?

Low creatinine levels are diagnosed with a common blood test that indicates creatinine levels. Doctors use further methods to identify the condition's root cause and prescribe treatment accordingly.

Can certain medications cause low creatinine levels?

No definite medication may cause lower serum creatinine levels in the blood. But some drugs used in kidney disease patients, like diuretics, medications for lowering high blood pressure, erythropoietin and others, can lead to a decrease in creatinine levels.

Ask your doctor about changing your dosage or switching to a different drug if you're on a medicine that lowers the level of creatinine.

Are there any lifestyle changes that can help increase creatinine levels?

Bringing certain changes in regular lifestyles, such as incorporating a nutritious diet and regular exercise, can increase creatinine levels in the body.  

  1. Diet may include red meat, lentils, legumes, eggs, etc. 
  2. Physical activities like walking, swimming, etc., in your everyday life may also help.

Can low creatinine levels affect a person's overall health?

Low creatinine level indicates malnutrition and lack of muscle mass in the body. If the condition persists, it can drastically affect a person’s quality of life.

When to worry about creatinine levels 7, and what does it indicate?

Creatinine level 7 refers to a serum creatinine quotient of 7 mg/dL, which is way beyond the normal range. It indicates severe kidney disease, and the patient should consult a nephrologist immediately for treatment.

When are serum creatinine levels considered higher than normal?

When serum creatinine levels go beyond 1.1 mg/dL in females and 1.2 mg/dL in males, it is higher than normal. Such conditions require professional medical attention as soon as possible.

What are treatments for managing high creatinine levels?

Your doctor may prescribe medications to reduce your creatinine levels. However, dietary changes are essential to manage high creatinine levels. Reduce foods rich in protein value and incorporate more fibre into your regular diet.

References

All the articles on HexaHealth are supported by verified medically-recognized sources such as; peer-reviewed academic research papers, research institutions, and medical journals. Our medical reviewers also check references of the articles to prioritize accuracy and relevance. Refer to our detailed editorial policy for more information.


  1. Ostermann M, Kashani K, Forni LG. The two sides of creatinine: both as bad as each other? Journal of Thoracic Disease [Internet]. 2016 Jul;8(7):E628–30. link
  2. NIDDK. Your Kidneys & How They Work | NIDDK [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases. 2018.link
  3. MedlinePlus. Creatinine Test: MedlinePlus Lab Test Information [Internet]. Medlineplus.gov. 2014. link
  4. Creatinine (Blood) - Health Encyclopedia - University of Rochester Medical Center [Internet]. Rochester.edu. 2019. link
  5. Higuera V. Low Creatinine: What You Need to Know [Internet]. Healthline. Healthline Media; 2017.link
  6. Low creatinine levels: Causes, symptoms, and treatments [Internet]. www.medicalnewstoday.com. 2017.link
  7. Davis JL. Antioxidant Superstars: Vegetables and Beans [Internet]. WebMD.link
  8. My age is 69. My creatinine fluctuates over that past 5 years from 1.0 to 1.4 with a 1.3 reading in 2005 and mostly 1.1, 1.0, 1.2 until a test in Nov 2011 showed a creatinine of 1.4 eGFR 50 (I had taken testosterone shots for the previous 12 weeks then stopped after the 1.4 creatinine level). The nelink
  9. What drugs are used to reduce creatinine levels in blood? What medicines are used to protect the kidney? Any medicine used for prostate problem? [Internet]. National Kidney Foundation. 2012.link

Updated on : 14 December 2023

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HexaHealth Care Team

HexaHealth Care Team brings you medical content covering many important conditions, procedures falling under different medical specialities. The content published is thoroughly reviewed by our panel of qualified doctors for its accuracy and relevance.

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